Hypercapnia downregulates hypoxia-induced lysyl oxidase expression in pulmonary artery smooth muscle cells via inhibiting transforming growth factor β
Animals
Apoptosis
Cell Hypoxia
Cell Survival
Cells, Cultured
Down-Regulation
Hypercapnia
/ metabolism
Hypertension, Pulmonary
/ metabolism
Male
Myocytes, Smooth Muscle
/ metabolism
Protein-Lysine 6-Oxidase
/ biosynthesis
Pulmonary Artery
/ metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Transforming Growth Factor beta1
/ antagonists & inhibitors
hypercapnia
hypoxia
lysyl oxidase
pulmonary hypertension
transforming growth factor-β1
Journal
Cell biochemistry and function
ISSN: 1099-0844
Titre abrégé: Cell Biochem Funct
Pays: England
ID NLM: 8305874
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
17
11
2018
revised:
17
02
2019
accepted:
01
03
2019
pubmed:
28
3
2019
medline:
9
5
2019
entrez:
28
3
2019
Statut:
ppublish
Résumé
Hypoxic pulmonary arterial hypertension is characterized by elevated pulmonary vascular resistance and remodelling. Transforming growth factor-β
Substances chimiques
Tgfb1 protein, mouse
0
Transforming Growth Factor beta1
0
Protein-Lysine 6-Oxidase
EC 1.4.3.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-202Subventions
Organisme : Natural Science Foundation of Zhejiang Province
ID : LY12H01002
Informations de copyright
© 2019 John Wiley & Sons, Ltd.