The Effect of a Frequency-Doubled Q-Switched Nd:YAG Laser on Hairless Mice Harboring Eumelanin and Pheomelanin in the Epidermis.
Nd:YAG laser
eumelanin
pheomelanin
Journal
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
ISSN: 1347-3409
Titre abrégé: J Nippon Med Sch
Pays: Japan
ID NLM: 100935589
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
29
3
2019
pubmed:
29
3
2019
medline:
25
4
2019
Statut:
ppublish
Résumé
For laser therapy, darker skin types should be carefully treated, however, the precise role of melanin content, subspecies, and the heat effect of the laser has not been well studied in vivo. We generated three groups of mice that have epidermal melanocytes producing only eumelanin, dominant pheomelanin, and no melanin. Using these mice, the effect of a frequency-doubled Nd:YAG laser was studied. The mouse epidermis that contained eumelanin underwent heat degeneration at a lower fluence when compared with the mouse epidermis with dominant pheomelanin. The mouse skin with no melanin did not show any degeneration of the epidermis. The effect of the Nd:YAG laser on the cells containing different melanin subspecies was shown to be different in an in vivo irradiation system.
Sections du résumé
BACKGROUND
BACKGROUND
For laser therapy, darker skin types should be carefully treated, however, the precise role of melanin content, subspecies, and the heat effect of the laser has not been well studied in vivo.
METHODS
METHODS
We generated three groups of mice that have epidermal melanocytes producing only eumelanin, dominant pheomelanin, and no melanin. Using these mice, the effect of a frequency-doubled Nd:YAG laser was studied.
RESULTS
RESULTS
The mouse epidermis that contained eumelanin underwent heat degeneration at a lower fluence when compared with the mouse epidermis with dominant pheomelanin. The mouse skin with no melanin did not show any degeneration of the epidermis.
CONCLUSION
CONCLUSIONS
The effect of the Nd:YAG laser on the cells containing different melanin subspecies was shown to be different in an in vivo irradiation system.
Identifiants
pubmed: 30918153
doi: 10.1272/jnms.JNMS.2019_86-5
doi:
Substances chimiques
Melanins
0
pheomelanin
0
eumelanin
12627-86-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM