Optimized dual-time-window protocols for quantitative [
Alzheimer’s disease
Amyloid
Florbetaben PET
Flutemetamol PET
Quantification
Simplified methods
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
27 Mar 2019
27 Mar 2019
Historique:
received:
30
11
2018
accepted:
11
03
2019
entrez:
29
3
2019
pubmed:
29
3
2019
medline:
29
3
2019
Statut:
epublish
Résumé
A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to static scans. A compromise can be achieved by implementing dual-time-window protocols. This study aimed to optimize these protocols for quantitative [ Rate constants for subjects across the Alzheimer's disease spectrum (i.e., non-displaceable binding potential (BP [ The length of the interval inversely correlates with the accuracy of the BP
Sections du résumé
BACKGROUND
BACKGROUND
A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to static scans. A compromise can be achieved by implementing dual-time-window protocols. This study aimed to optimize these protocols for quantitative [
METHODS
METHODS
Rate constants for subjects across the Alzheimer's disease spectrum (i.e., non-displaceable binding potential (BP
RESULTS
RESULTS
[
CONCLUSIONS
CONCLUSIONS
The length of the interval inversely correlates with the accuracy of the BP
Identifiants
pubmed: 30919133
doi: 10.1186/s13550-019-0499-4
pii: 10.1186/s13550-019-0499-4
pmc: PMC6437225
doi:
Types de publication
Journal Article
Langues
eng
Pagination
32Subventions
Organisme : Innovative Medicines Initiative
ID : 115952
Organisme : Ramón y Cajal
ID : RYC-2013-13054
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