Effect of a session of intensive exercise with ginseng supplementation on histone H3 protein methylation of skeletal muscle of nonathlete men.
ginseng supplementation
histone H3 protein (k-36) methylation
severe periodic exercises
Journal
Molecular genetics & genomic medicine
ISSN: 2324-9269
Titre abrégé: Mol Genet Genomic Med
Pays: United States
ID NLM: 101603758
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
25
08
2018
revised:
07
01
2019
accepted:
01
03
2019
pubmed:
29
3
2019
medline:
27
6
2019
entrez:
29
3
2019
Statut:
ppublish
Résumé
The pressure and stress caused by some intense exercises cause changes in histone proteins and gene expression. The aim of this study was to investigate the effect of one session of intensive exercise with supplementation of ginseng, on the methylation of H3K-36 histone protein in skeletal muscle of young nonathlete men. After the approval by the ethics committee, 12 untrained male subjects were randomly assigned to either exercise group (six subjects) or exercise and supplement group. First, from both groups, the muscular sample was taken from the broad-lateral muscle of the subjects. Immediately after the muscle biopsy, exercise and exercise + supplement groups completed the exercise protocol. During this period, the exercise + supplement group consumed ginseng supplementation and took placebo group. Immediately after exercise, all subjects were retested. There was no significant increase in histone H3-k36 protein methylation in the intergroup between exercise + supplementation and exercise. There was a significant difference within the training group but there was no difference in the exercise + supplementation group. The methylation caused by intense physical pressure, can be reduced by ginseng extract.
Identifiants
pubmed: 30920174
doi: 10.1002/mgg3.651
pmc: PMC6503167
doi:
Substances chimiques
Histones
0
Plant Extracts
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e651Informations de copyright
© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.
Références
J Musculoskelet Neuronal Interact. 2013 Jun;13(2):133-46
pubmed: 23728100
Evid Based Complement Alternat Med. 2005 Dec;2(4):529-36
pubmed: 16322811
Mol Genet Genomic Med. 2019 May;7(5):e651
pubmed: 30920174
Cell. 2009 Jul 10;138(1):129-45
pubmed: 19596240
PLoS Genet. 2009 Mar;5(3):e1000435
pubmed: 19325889
Hum Mol Genet. 2001 Apr;10(7):693-8
pubmed: 11257101
Genes Dev. 2011 Jul 1;25(13):1345-58
pubmed: 21724828
J Physiol. 2009 Dec 15;587(Pt 24):5951-8
pubmed: 19884317
J Clin Lab Anal. 2001;15(4):199-209
pubmed: 11436203
Nucleic Acids Res. 2008 May;36(8):2690-9
pubmed: 18353861
Nature. 1997 Sep 18;389(6648):251-60
pubmed: 9305837
J Sports Sci. 2010 Sep;28(11):1243-50
pubmed: 20845210
Bioessays. 2001 Sep;23(9):820-30
pubmed: 11536294
J Ethnopharmacol. 1994 Dec;44(3):131-5
pubmed: 7898119
Genes Dev. 2004 Jun 1;18(11):1251-62
pubmed: 15145825
JAMA. 1979 Apr 13;241(15):1614-5
pubmed: 430716
Cell. 2007 Feb 23;128(4):707-19
pubmed: 17320508
Cell. 2007 Feb 23;128(4):693-705
pubmed: 17320507
FASEB J. 2005 Sep;19(11):1498-500
pubmed: 15985525
J Clin Invest. 2007 Sep;117(9):2459-67
pubmed: 17786239
PLoS One. 2009 Jun 12;4(6):e5882
pubmed: 19521516
Mol Cell. 2006 Aug 4;23(3):289-96
pubmed: 16885019
J Physiol. 2010 Mar 15;588(Pt 6):905-6
pubmed: 20231147
J Appl Physiol (1985). 2011 Jan;110(1):258-63
pubmed: 21030677
Am J Chin Med. 2007;35(2):329-39
pubmed: 17436372
Mol Microbiol. 2004 Aug;53(3):771-5
pubmed: 15255891
Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8697-702
pubmed: 18559847
J Strength Cond Res. 2010 May;24(5):1389-98
pubmed: 20386477
Eur Respir J. 2005 Mar;25(3):431-40
pubmed: 15738285
Cell. 2007 Feb 23;128(4):669-81
pubmed: 17320505
Eukaryot Cell. 2005 Aug;4(8):1446-54
pubmed: 16087749
Clin Ther. 1991 May-Jun;13(3):373-82
pubmed: 1954639