Arterial stiffness as a risk factor for cardiovascular events and all-cause mortality in people with Type 2 diabetes.
Adolescent
Adult
Aged
Ankle Brachial Index
Blood Pressure
Cardiovascular Diseases
/ diagnosis
Carotid Arteries
/ diagnostic imaging
Cause of Death
Cohort Studies
Diabetes Mellitus, Type 2
/ complications
Diabetic Angiopathies
/ diagnosis
Female
Femoral Artery
/ diagnostic imaging
Humans
Male
Middle Aged
Prospective Studies
Pulse Wave Analysis
Risk Factors
Vascular Stiffness
/ physiology
Young Adult
Journal
Diabetic medicine : a journal of the British Diabetic Association
ISSN: 1464-5491
Titre abrégé: Diabet Med
Pays: England
ID NLM: 8500858
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
accepted:
25
03
2019
pubmed:
29
3
2019
medline:
29
5
2020
entrez:
29
3
2019
Statut:
ppublish
Résumé
To quantify the risk of different non-invasive arterial stiffness measurements with macrovascular disease and all-cause mortality in high-risk people with Type 2 diabetes. We conducted a prospective cohort study of 1910 people with Type 2 diabetes included in the Second Manifestations of ARTerial disease (SMART) study. Arterial stiffness was assessed by brachial artery pulse pressure, normal range (≥0.9) ankle-brachial index and carotid artery distension. Cox regression was used to evaluate the effects of arterial stiffness on risk of cardiovascular events (composite of myocardial infarction, stroke and vascular mortality) and all-cause mortality. A total of 380 new cardiovascular events and 436 deaths occurred during a median (interquartile range) follow-up of 7.5 (4.1-11.0) years. A 10-mmHg higher brachial pulse pressure was related to higher hazard of cardiovascular events (hazard ratio 1.09, 95% CI 1.02 to 1.16) and all-cause mortality (hazard ratio 1.10, 95% CI 1.03 to 1.16). A 0.1-point lower ankle-brachial index within the normal range was related to a higher hazard of cardiovascular events (hazard ratio 1.13, 95% CI 1.01 to 1.27) and all-cause mortality (hazard ratio 1.17, 95% CI 1.04 to 1.31). A one-unit (10 Increased arterial stiffness, as measured by either increased pulse pressure, normal-range ankle-brachial index or carotid artery distensibility coefficient, is related to increased hazard of cardiovascular events and all-cause mortality in people with Type 2 diabetes.
Identifiants
pubmed: 30920676
doi: 10.1111/dme.13954
pmc: PMC6767543
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1125-1132Informations de copyright
© 2019 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.
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