Treatment response of lithium augmentation in geriatric compared to non-geriatric patients with treatment-resistant depression.
Aged
Aged, 80 and over
Antidepressive Agents
/ therapeutic use
Cohort Studies
Depression
Depressive Disorder, Major
/ drug therapy
Depressive Disorder, Treatment-Resistant
/ drug therapy
Drug Therapy, Combination
Female
Humans
Lithium Carbonate
/ therapeutic use
Male
Middle Aged
Prospective Studies
Treatment Outcome
Efficacy
Geriatric patients
Lithium augmentation
Treatment-resistant depression
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
20
12
2018
revised:
09
03
2019
accepted:
19
03
2019
pubmed:
29
3
2019
medline:
13
7
2019
entrez:
29
3
2019
Statut:
ppublish
Résumé
Lithium augmentation (LA) of antidepressants is an effective strategy for treatment-resistant depression (TRD). Nevertheless, it is rarely used in geriatric patients. The purpose of this study was to investigate treatment response of LA in geriatric compared to non-geriatric patients. In a prospective multicenter cohort study, severity of depression was measured weekly in 167 patients with unipolar depression (n Geriatric patients showed a significantly better response to LA compared to non-geriatric patients (Hazard Ratio = 1.91; p = 0.04). An important limitation of our study is the lack of a control group of LA and the missing evaluation of side effects in both groups. This is the first study investigating the efficacy of LA for TRD in geriatric compared to non-geriatric patients. Our data suggest that LA is an effective treatment option in geriatric patients that clinicians might consider more frequently and earlier on in the course of treatment.
Sections du résumé
BACKGROUND
Lithium augmentation (LA) of antidepressants is an effective strategy for treatment-resistant depression (TRD). Nevertheless, it is rarely used in geriatric patients. The purpose of this study was to investigate treatment response of LA in geriatric compared to non-geriatric patients.
METHOD
In a prospective multicenter cohort study, severity of depression was measured weekly in 167 patients with unipolar depression (n
RESULTS
Geriatric patients showed a significantly better response to LA compared to non-geriatric patients (Hazard Ratio = 1.91; p = 0.04).
LIMITATIONS
An important limitation of our study is the lack of a control group of LA and the missing evaluation of side effects in both groups.
CONCLUSIONS
This is the first study investigating the efficacy of LA for TRD in geriatric compared to non-geriatric patients. Our data suggest that LA is an effective treatment option in geriatric patients that clinicians might consider more frequently and earlier on in the course of treatment.
Identifiants
pubmed: 30921597
pii: S0165-0327(18)33234-8
doi: 10.1016/j.jad.2019.03.057
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Lithium Carbonate
2BMD2GNA4V
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
136-140Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.