Personalized transcranial alternating current stimulation (tACS) and physical therapy to treat motor and cognitive symptoms in Parkinson's disease: A randomized cross-over trial.
Aged
Aged, 80 and over
Brain Waves
/ physiology
Breathing Exercises
/ methods
Cognitive Dysfunction
/ etiology
Combined Modality Therapy
Cross-Over Studies
Double-Blind Method
Exercise Therapy
/ methods
Female
Humans
Hypokinesia
/ etiology
Male
Middle Aged
Outcome Assessment, Health Care
Parkinson Disease
/ complications
Precision Medicine
Psychomotor Performance
/ physiology
Severity of Illness Index
Transcranial Direct Current Stimulation
/ methods
Electroencephalography
Neurophysiology
Neurotherapeutic target
Non-invasive brain stimulation (NIBS)
Unified Parkinson's disease rating scale (UPDRS III)
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
09
07
2018
revised:
22
01
2019
accepted:
10
03
2019
pubmed:
29
3
2019
medline:
18
1
2020
entrez:
29
3
2019
Statut:
ppublish
Résumé
Abnormal cortical oscillations are markers of Parkinson's Disease (PD). Transcranial alternating current stimulation (tACS) can modulate brain oscillations and possibly impact on behaviour. Mapping of cortical activity (prevalent oscillatory frequency and topographic scalp distribution) may provide a personalized neurotherapeutic target and guide non-invasive brain stimulation. This is a cross-over, double blinded, randomized trial. Electroencephalogram (EEG) from participants with PD referred to Specialist Clinic, University Hospital, were recorded. TACS frequency and electrode position were individually defined based on statistical comparison of EEG power spectra maps with normative data from our laboratory. Stimulation frequency was set according to the EEG band displaying higher power spectra (with beta excess on EEG map, tACS was set at 4 Hz; with theta excess, tACS was set at 30 Hz). Participants were randomized to tACS or random noise stimulation (RNS), 5 days/week for 2-weeks followed by ad hoc physical therapy. EEG, motor (Unified Parkinson's Disease Rating Scale-motor: UPDRS III), neuropsychological (frontal, executive and memory tests) performance and mood were measured before (T
Identifiants
pubmed: 30921609
pii: S2213-1582(19)30118-4
doi: 10.1016/j.nicl.2019.101768
pmc: PMC6439208
pii:
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
101768Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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