Early-childhood social reticence predicts SCR-BOLD coupling during fear extinction recall in preadolescent youth.
Conditioning
Coupling
Extinction recall
Skin conductance response
Temperament
fMRI
Journal
Developmental cognitive neuroscience
ISSN: 1878-9307
Titre abrégé: Dev Cogn Neurosci
Pays: Netherlands
ID NLM: 101541838
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
03
05
2018
revised:
16
11
2018
accepted:
11
12
2018
pubmed:
29
3
2019
medline:
16
11
2019
entrez:
29
3
2019
Statut:
ppublish
Résumé
Social Reticence (SR) is a temperament construct identified in early childhood that is expressed as shy, anxiously avoidant behavior and, particularly when stable, robustly associated with risk for anxiety disorders. Threat circuit function may develop differently for children high on SR than low on SR. We compared brain function and behavior during extinction recall in a sample of 11-to-15-year-old children characterized in early childhood on a continuum of SR. Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. Whereas self-report and psychophysiological measures of differential conditioning, extinction, and extinction recall were largely similar across participants, SR-related differences in brain function emerged during extinction recall. Specifically, childhood SR was associated with a distinct pattern of hemodynamic-autonomic covariation in the brain when recalling extinguished threat and safety cues. SR and attention focus impacted associations between trial-by-trial variation in autonomic responding and in brain activation. These interactions occurred in three main brain areas: the anterior insular cortex (AIC), the anterior subdivision of the medial cingulate cortex (aMCC), and the dorsolateral prefrontal cortex (dlPFC). This pattern of SCR-BOLD coupling may reflect selective difficulty tracking safety in a temperamentally at-risk population.
Identifiants
pubmed: 30921634
pii: S1878-9293(18)30097-5
doi: 10.1016/j.dcn.2018.12.003
pmc: PMC6969221
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
100605Subventions
Organisme : NICHD NIH HHS
ID : R37 HD017899
Pays : United States
Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.
Références
J Neurosci. 2016 Nov 23;36(47):11987-11998
pubmed: 27881783
Neuroimage. 2001 Nov;14(5):1070-9
pubmed: 11697938
Neuron. 2011 Feb 10;69(3):563-71
pubmed: 21315265
Neuron. 2016 Oct 19;92(2):505-517
pubmed: 27720488
Neuroimage. 2011 Mar 1;55(1):389-400
pubmed: 21111828
Brain Struct Funct. 2010 Jun;214(5-6):535-49
pubmed: 20512367
Dev Sci. 2010 Jan 1;13(1):201-12
pubmed: 20121876
Brain. 2001 May;124(Pt 5):1003-12
pubmed: 11335702
Neuroimage. 2005 Jul 15;26(4):1193-200
pubmed: 15961053
Rev Neurosci. 1999;10(1):49-57
pubmed: 10356991
Am J Psychiatry. 2013 Oct;170(10):1195-204
pubmed: 23929092
Auton Neurosci. 2011 Apr 26;161(1-2):34-42
pubmed: 20926356
Child Dev. 1996 Feb;67(1):218-35
pubmed: 8605830
Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):878-82
pubmed: 8430101
Psychophysiology. 1994 Sep;31(5):427-38
pubmed: 7972597
Psychophysiology. 2011 Feb;48(2):162-75
pubmed: 20557480
Am J Psychiatry. 2017 Feb 1;174(2):125-134
pubmed: 27794690
Neuroimage. 2004 May;22(1):243-51
pubmed: 15110014
Science. 2000 Jun 9;288(5472):1835-8
pubmed: 10846167
Biol Psychiatry. 2014 Jun 1;75(11):909-15
pubmed: 24001473
Biol Psychiatry. 2006 Aug 15;60(4):383-7
pubmed: 16780813
J Neurosci. 2006 Sep 13;26(37):9503-11
pubmed: 16971534
Child Dev. 2002 Mar-Apr;73(2):483-95
pubmed: 11949904
J Comp Neurol. 1982 Nov 20;212(1):38-52
pubmed: 7174907
Trends Cogn Sci. 2011 Feb;15(2):85-93
pubmed: 21167765
PLoS One. 2012;7(11):e50120
pubmed: 23189183
Nat Neurosci. 2011 Sep 11;14(10):1250-2
pubmed: 21909088
Annu Rev Psychol. 2009;60:141-71
pubmed: 18851686
Child Dev. 1992 Apr;63(2):325-35
pubmed: 1611937
Neuron. 1998 May;20(5):947-57
pubmed: 9620699
Neuroimage. 2005 Nov 15;28(3):618-26
pubmed: 16081303
Am J Psychiatry. 2010 Jan;167(1):47-55
pubmed: 19917595
J Child Psychol Psychiatry. 2017 Nov;58(11):1276-1286
pubmed: 28736915
J Neurosci. 2000 Apr 15;20(8):3033-40
pubmed: 10751455
Nat Rev Neurosci. 2009 Jan;10(1):59-70
pubmed: 19096369
Dev Psychol. 2014 Oct;50(10):2311-2323
pubmed: 25181648
Child Dev. 1994 Feb;65(1):129-37
pubmed: 8131643
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
Brain Connect. 2017 Apr;7(3):152-171
pubmed: 28398812
J Exp Child Psychol. 2016 Jun;146:95-105
pubmed: 26922673
Neurosci Biobehav Rev. 2018 May;88:16-25
pubmed: 29530516
Cereb Cortex. 2007 Jul;17(7):1664-71
pubmed: 16963517
Nat Neurosci. 2005 Apr;8(4):519-26
pubmed: 15750588
Am J Psychiatry. 2014 Nov 1;171(11):1162-73
pubmed: 25157566
J Abnorm Psychol. 2009 May;118(2):311-21
pubmed: 19413406
J Cogn Neurosci. 2011 Oct;23(10):3132-45
pubmed: 21391763
Biol Psychiatry. 2007 Sep 1;62(5):446-54
pubmed: 17217927
Child Dev. 2001 Sep-Oct;72(5):1394-408
pubmed: 11699677
Nat Neurosci. 2001 Apr;4(4):437-41
pubmed: 11276236
Neuron. 2013 Feb 20;77(4):624-38
pubmed: 23439117
Brain. 2003 Oct;126(Pt 10):2139-52
pubmed: 12821513
Neuroimage. 2002 Jun;16(2):331-48
pubmed: 12030820
Neuroimage. 2005 Oct 1;27(4):885-95
pubmed: 15996878
Psychol Sci. 2009 Aug;20(8):1009-18
pubmed: 19594857
Neuroimage. 2012 Mar;60(1):787-99
pubmed: 22227141
Biol Psychol. 2013 Feb;92(2):306-14
pubmed: 23046903
Behav Neurosci. 2010 Aug;124(4):478-89
pubmed: 20695647
Neuroimage. 2010 Jan 15;49(2):1760-8
pubmed: 19786103
Dev Psychopathol. 2018 Feb;30(1):179-189
pubmed: 28534459
Behav Res Ther. 2009 Feb;47(2):111-8
pubmed: 19027893
Dev Psychol. 2011 May;47(3):765-80
pubmed: 21114347
Psychol Sci. 2016 Jun;27(6):821-35
pubmed: 27150109
Nat Rev Neurosci. 2011 Mar;12(3):154-67
pubmed: 21331082
Biol Psychiatry. 2017 Nov 1;82(9):669-678
pubmed: 27837919
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16318-23
pubmed: 22988092
Depress Anxiety. 2015 Apr;32(4):277-88
pubmed: 25427438