Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects.
Adult
Biomarkers
/ analysis
Case-Control Studies
DNA Methylation
Epigenesis, Genetic
Female
Follow-Up Studies
Humans
Insulin Resistance
Insulin-Like Growth Factor Binding Protein 2
/ genetics
Intra-Abdominal Fat
/ metabolism
Leptin
/ metabolism
Male
Middle Aged
Obesity
/ genetics
Prognosis
RNA, Messenger
/ genetics
Subcutaneous Fat
/ metabolism
Adipose tissues
DNA methylation
IGFBP2
Obesity
mRNA expression
Journal
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
ISSN: 1532-2238
Titre abrégé: Growth Horm IGF Res
Pays: Scotland
ID NLM: 9814320
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
08
10
2018
revised:
18
03
2019
accepted:
19
03
2019
pubmed:
29
3
2019
medline:
3
8
2019
entrez:
29
3
2019
Statut:
ppublish
Résumé
Insulin-like growth factor binding-protein 2 (IGFBP-2) is secreted by differentiating white adipocytes. Clinical studies demonstrate that circulating IGFBP-2 levels associated inversely with body mass index (BMI) and insulin resistance. To explore possible epigenetic changes of the IGFBP2 gene in obesity, we analyzed DNA methylation and mRNA expression in adipocytes from different depots. Healthy lean controls (BMI = 24.5 ± 0.3 kg/m
Identifiants
pubmed: 30921666
pii: S1096-6374(19)30014-0
doi: 10.1016/j.ghir.2019.03.002
pii:
doi:
Substances chimiques
Biomarkers
0
Insulin-Like Growth Factor Binding Protein 2
0
Leptin
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
31-36Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.