Curcumin loaded nanoparticles as efficient photoactive formulations against gram-positive and gram-negative bacteria.

The constant increase in multi-resistant bacterial strains and the decline in the number of newly approved antibiotics necessitate the development of alternative approaches to antibiotic treatment. In this study, a modern alternative approach to antibiotic therapy using photosensitiser encapsulated polymeric nanoparticles is presented. Cationic nanoparticles were prepared using a biodegradable and biocompatible polymer poly (lactic-co-glycolic acid), a stabiliser poly (vinyl alcohol) and chitosan. Dynamic light scattering and laser Doppler anemometry were used to determine particle size distribution and ζ-potential respectively. To quantify the antibacterial photodynamic effect of the nanoparticles, in vitro studies were performed using Staphylococcus saprophyticus subsp. bovis and Escherichia coli DH5 alpha to represent both a gram-positive as well as a gram-negative strain. It was demonstrated that the particle ζ-potential significantly influenced the antibacterial phototoxicity, gaining up to 3 log

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