Horner Syndrome Secondary to Metastatic Squamous Cell Carcinoma in the Neck: A Case Series.
Horner
carotid encasement
head neck cancer
metastatic
squamous carcinoma
Journal
Ear, nose, & throat journal
ISSN: 1942-7522
Titre abrégé: Ear Nose Throat J
Pays: United States
ID NLM: 7701817
Informations de publication
Date de publication:
Historique:
pubmed:
30
3
2019
medline:
18
12
2019
entrez:
30
3
2019
Statut:
ppublish
Résumé
Horner syndrome caused by metastatic squamous cell carcinoma of the head and neck is not common, and when diagnosed, may have serious clinical implications. We aim at highlighting the clinical significance of this finding. We retrospectively reviewed charts of 6 patients with Horner syndrome secondary to metastatic head and neck squamous cell carcinoma (HNSCC) in the neck. All 6 patients had pathologically confirmed nodal metastatic HNSCC. There was one unknown primary and in the remaining 5 patients the primary tumor was identified in the oropharynx, larynx, and oral cavity. Three patients died within 1 month of diagnosis, before initiation of any treatment. One patient received radiation only while 2 patients received chemoradiation with cisplatin as the tumors were unresectable given carotid sheath involvement. Median survival was 4.5 months. Only 1 out of the 6 patients survived and had complete resolution of Horner syndrome after treatment. This is the first case series of neck metastasis from mucosal HNSCC as an unusual cause of Horner syndrome and is usually associated with very poor prognosis.
Sections du résumé
BACKGROUND
BACKGROUND
Horner syndrome caused by metastatic squamous cell carcinoma of the head and neck is not common, and when diagnosed, may have serious clinical implications. We aim at highlighting the clinical significance of this finding.
METHODS
METHODS
We retrospectively reviewed charts of 6 patients with Horner syndrome secondary to metastatic head and neck squamous cell carcinoma (HNSCC) in the neck.
RESULTS
RESULTS
All 6 patients had pathologically confirmed nodal metastatic HNSCC. There was one unknown primary and in the remaining 5 patients the primary tumor was identified in the oropharynx, larynx, and oral cavity. Three patients died within 1 month of diagnosis, before initiation of any treatment. One patient received radiation only while 2 patients received chemoradiation with cisplatin as the tumors were unresectable given carotid sheath involvement. Median survival was 4.5 months. Only 1 out of the 6 patients survived and had complete resolution of Horner syndrome after treatment.
CONCLUSION
CONCLUSIONS
This is the first case series of neck metastasis from mucosal HNSCC as an unusual cause of Horner syndrome and is usually associated with very poor prognosis.
Identifiants
pubmed: 30922108
doi: 10.1177/0145561319838248
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM