Head and neck cancer and occupational exposure to leather dust: results from the ICARE study, a French case-control study.
Aged
Air Pollutants, Occupational
/ analysis
Carcinogens
/ analysis
Case-Control Studies
Dust
/ analysis
Female
France
/ epidemiology
Head and Neck Neoplasms
/ epidemiology
Humans
Male
Manufacturing Industry
Middle Aged
Occupational Diseases
/ epidemiology
Occupational Exposure
/ analysis
Odds Ratio
Case control study
Epidemiology
Head and neck cancer
Leather dust
Occupational health
Journal
Environmental health : a global access science source
ISSN: 1476-069X
Titre abrégé: Environ Health
Pays: England
ID NLM: 101147645
Informations de publication
Date de publication:
29 03 2019
29 03 2019
Historique:
received:
19
10
2018
accepted:
20
03
2019
entrez:
30
3
2019
pubmed:
30
3
2019
medline:
9
5
2019
Statut:
epublish
Résumé
Leather dust is an established carcinogen of the sinonasal cavities; however, evidence is lacking regarding its association with other head and neck cancers (HNC). To date, few studies have been conducted on the association between occupational leather dust exposure and the risk of oral, pharyngeal, and laryngeal cancers. The objective of this study was to investigate the association between the risk of HNC and occupational exposure to leather dust. Lifestyle habits and occupational history were collected for 2161 patients with squamous cell carcinoma of oral cavity, pharynx, and larynx, and 3555 controls, using a standardized questionnaire. Occupational exposure to leather dust was assessed using a job-exposure matrix. Odds ratios (OR) and 95% confidence intervals (CI) for HNC globally and by subsite were estimated using multivariate unconditional, and polytomous logistic regressions, respectively. Cumulative lifetime exposure to leather dust < 6 mg/m Our study did not provide enough evidence for an increased risk of HNC related to occupational exposure to leather dust. Further studies are needed to understand the risks of specific tasks in the leather industry.
Sections du résumé
BACKGROUND
Leather dust is an established carcinogen of the sinonasal cavities; however, evidence is lacking regarding its association with other head and neck cancers (HNC). To date, few studies have been conducted on the association between occupational leather dust exposure and the risk of oral, pharyngeal, and laryngeal cancers. The objective of this study was to investigate the association between the risk of HNC and occupational exposure to leather dust.
METHODS
Lifestyle habits and occupational history were collected for 2161 patients with squamous cell carcinoma of oral cavity, pharynx, and larynx, and 3555 controls, using a standardized questionnaire. Occupational exposure to leather dust was assessed using a job-exposure matrix. Odds ratios (OR) and 95% confidence intervals (CI) for HNC globally and by subsite were estimated using multivariate unconditional, and polytomous logistic regressions, respectively.
RESULTS
Cumulative lifetime exposure to leather dust < 6 mg/m
CONCLUSION
Our study did not provide enough evidence for an increased risk of HNC related to occupational exposure to leather dust. Further studies are needed to understand the risks of specific tasks in the leather industry.
Identifiants
pubmed: 30922305
doi: 10.1186/s12940-019-0469-3
pii: 10.1186/s12940-019-0469-3
pmc: PMC6440008
doi:
Substances chimiques
Air Pollutants, Occupational
0
Carcinogens
0
Dust
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
27Investigateurs
Anne-Valérie Guizard
(AV)
Arlette Danzon
(A)
Anne-Sophie Woronoff
(AS)
Michel Velten
(M)
Antoine Buemi
(A)
Émilie Marrer
(É)
Brigitte Trétarre
(B)
Marc Colonna
(M)
Patricia Delafosse
(P)
Paolo Bercelli
(P)
Florence Molinié
(F)
Simona Bara
(S)
Bénédicte Lapotre-Ledoux
(B)
Nicole Raverdy
(N)
Sylvie Cénée
(S)
Oumar Gaye
(O)
Florence Guida
(F)
Farida Lamkarkach
(F)
Loredana Radoï
(L)
Marie Sanchez
(M)
Isabelle Stücker
(I)
Matthieu Carton
(M)
Diane Cyr
(D)
Annie Schmaus
(A)
Joëlle Févotte
(J)
Corinne Pilorget
(C)
Gwenn Menvielle
(G)
Danièle Luce
(D)
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