Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage.

Brain Injuries / etiology Cerebral Hemorrhage / complications Cytokines / immunology Humans Inflammation / complications
Cytokines ICH Inflammatory reaction Secondary injury

Journal

Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121

Informations de publication

Date de publication:
07 2019
Historique:
received: 04 09 2018
revised: 07 03 2019
accepted: 16 03 2019
pubmed: 30 3 2019
medline: 28 4 2020
entrez: 30 3 2019
Statut: ppublish

Résumé

Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Inflammatory cytokines are important participants in secondary injury after ICH. Increases in proinflammatory cytokines may aggravate the tissue injury, whereas increases in anti-inflammatory cytokines might be protective in the ICH brain. Inflammatory cytokines have been studied as therapeutic targets in a variety of acute and chronic brain diseases; however, studies on ICH are limited. This review summarizes the roles and functions of various pro- and anti-inflammatory cytokines in secondary brain injury after ICH and discusses pathogenic mechanisms and emerging therapeutic strategies and directions for treatment of ICH.

Identifiants

DOI: 10.1016/j.pneurobio.2019.03.003 PMID: 30923023
pubmed: 30923023
pii: S0301-0082(18)30142-4
doi: 10.1016/j.pneurobio.2019.03.003
pii:
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101610

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS078026
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT007317
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102583
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105894
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Huimin Zhu (H)

Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China.

Zhiqiang Wang (Z)

Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China.

Jixu Yu (J)

Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China; Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China; Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.

Xiuli Yang (X)

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Feng He (F)

Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China.

Zhenchuan Liu (Z)

Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China. Electronic address: lzhenchuan@sohu.com.

Fengyuan Che (F)

Department of Neurology, Linyi People's Hospital, Linyi, Shandong 276003, China; Central laboratory, Linyi People's Hospital, Linyi, Shandong 276003, China. Electronic address: che1971@126.com.

Xuemei Chen (X)

Department of Anatomy, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China.

Honglei Ren (H)

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Michael Hong (M)

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Jian Wang (J)

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: jwang79@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Role and mechanisms of cytokines in the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hémorragie › Hémorragies intracrâniennes › Hémorragie cérébrale › Role and mechanisms of cytokines in the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Role and mechanisms of cytokines in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role and mechanisms of cytokines in the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Role and mechanisms of cytokines in the...