Functional ultrasound imaging of the brain reveals propagation of task-related brain activity in behaving primates.
Animals
Brain
/ diagnostic imaging
Cerebrovascular Circulation
Cognition
/ physiology
Echoencephalography
Eye Movements
/ physiology
Frontal Lobe
/ diagnostic imaging
Functional Neuroimaging
Gyrus Cinguli
/ diagnostic imaging
Macaca
Neural Pathways
/ diagnostic imaging
Saccades
/ physiology
Task Performance and Analysis
Ultrasonography, Doppler, Transcranial
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 03 2019
28 03 2019
Historique:
received:
08
08
2018
accepted:
04
03
2019
entrez:
30
3
2019
pubmed:
30
3
2019
medline:
23
4
2019
Statut:
epublish
Résumé
Neuroimaging modalities such as MRI and EEG are able to record from the whole brain, but this comes at the price of either limited spatiotemporal resolution or limited sensitivity. Here, we show that functional ultrasound imaging (fUS) of the brain is able to assess local changes in cerebral blood volume during cognitive tasks, with sufficient temporal resolution to measure the directional propagation of signals. In two macaques, we observed an abrupt transient change in supplementary eye field (SEF) activity when animals were required to modify their behaviour associated with a change of saccade tasks. SEF activation could be observed in a single trial, without averaging. Simultaneous imaging of anterior cingulate cortex and SEF revealed a time delay in the directional functional connectivity of 0.27 ± 0.07 s and 0.9 ± 0.2 s for both animals. Cerebral hemodynamics of large brain areas can be measured at high spatiotemporal resolution using fUS.
Identifiants
pubmed: 30923310
doi: 10.1038/s41467-019-09349-w
pii: 10.1038/s41467-019-09349-w
pmc: PMC6438968
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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