The emerging role of exosomes in mental disorders.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
28 03 2019
28 03 2019
Historique:
received:
15
11
2018
accepted:
12
03
2019
revised:
13
02
2019
entrez:
30
3
2019
pubmed:
30
3
2019
medline:
10
1
2020
Statut:
epublish
Résumé
Exosomes are a class of extracellular vesicles of endocytic origin, which are released by cells and are accessible in biofluids, such as saliva, urine, and plasma. These vesicles are enriched with small RNA, and they play a role in many physiological processes. In the brain, they are involved in processes including synaptic plasticity, neuronal stress response, cell-to-cell communication and neurogenesis. While exosomes have been implicated previously in cancer and neurodegenerative diseases, research regarding their role in mental disorders remains scarce. Given their functional significance in the brain, investigation in this field is warranted. Additionally, because exosomes can cross the blood-brain barrier, they may serve as accessible biomarkers of neural dysfunction. Studying exosomes may provide information towards diagnosis and therapeutic intervention, and specifically those derived from the brain may provide a mechanistic view of the disease phenotype. This review will discuss the roles of exosomes in the brain, and relate novel findings to current insights into mental disorders.
Identifiants
pubmed: 30923321
doi: 10.1038/s41398-019-0459-9
pii: 10.1038/s41398-019-0459-9
pmc: PMC6438960
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
122Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : FDN148374
Pays : International
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada)
ID : EGM141899
Pays : International
Références
J Circ Biomark. 2015 Jul 17;4:7
pubmed: 28936243
Int J Neuropsychopharmacol. 2019 Mar 1;22(3):232-246
pubmed: 30535257
J Neurosci Res. 2018 Jan;96(1):45-52
pubmed: 28718905
Nat Med. 2014 Jul;20(7):764-8
pubmed: 24908571
J Neuroinflammation. 2018 Aug 27;15(1):239
pubmed: 30149804
Nat Protoc. 2012 Jun 14;7(7):1311-26
pubmed: 22722367
J Affect Disord. 2018 Nov;240:88-98
pubmed: 30059939
Glia. 2016 Jun;64(6):896-910
pubmed: 26992135
Hum Mol Genet. 2008 Apr 15;17(8):1156-68
pubmed: 18184693
Sci Rep. 2018 Mar 2;8(1):3945
pubmed: 29500443
J Extracell Vesicles. 2016 Nov 17;5:32570
pubmed: 27863537
J Thromb Haemost. 2014 Jul;12(7):1182-92
pubmed: 24818656
J Exp Neurosci. 2016 Aug 08;10(Suppl 1):1-9
pubmed: 27547038
J Neuroinflammation. 2016 Nov 16;13(1):292
pubmed: 27852330
PLoS One. 2012;7(3):e30679
pubmed: 22427800
J Neuroinflammation. 2018 Jan 08;15(1):8
pubmed: 29310666
Acta Pharmacol Sin. 2018 Apr;39(4):501-513
pubmed: 29219950
J Extracell Vesicles. 2014 Aug 04;3:
pubmed: 25143819
J Cell Biochem. 2010 Oct 1;111(2):488-96
pubmed: 20533300
Acta Neuropathol. 2018 Jul;136(1):41-56
pubmed: 29934873
Acta Neuropathol Commun. 2017 Sep 13;5(1):71
pubmed: 28903781
J Control Release. 2015 Jun 10;207:18-30
pubmed: 25836593
FASEB J. 2016 Nov;30(11):3853-3859
pubmed: 27511944
Biol Psychiatry. 2004 Feb 1;55(3):225-33
pubmed: 14744462
BMC Genomics. 2012 Aug 01;13:357
pubmed: 22849433
Can J Psychiatry. 2015 Oct;60(10):460-3
pubmed: 26720193
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209
pubmed: 25830558
Acta Neuropathol Commun. 2017 Aug 29;5(1):65
pubmed: 28851452
Dialogues Clin Neurosci. 2009;11(3):239-55
pubmed: 19877493
Sci Rep. 2015 Dec 03;5:17543
pubmed: 26633001
Eur Neuropsychopharmacol. 2013 Sep;23(9):1067-71
pubmed: 23183130
Nat Biotechnol. 2011 Apr;29(4):341-5
pubmed: 21423189
J Extracell Vesicles. 2017 Apr 19;6(1):1302705
pubmed: 28473883
J Biol Chem. 1987 Jul 5;262(19):9412-20
pubmed: 3597417
J Extracell Vesicles. 2017 Jun 20;6(1):1329476
pubmed: 28717422
J Extracell Vesicles. 2014 Dec 22;3:26913
pubmed: 25536934
Blood. 2012 Jan 19;119(3):646-8
pubmed: 22262739
Acta Neuropathol Commun. 2018 Feb 15;6(1):10
pubmed: 29448966
J Extracell Vesicles. 2014 Mar 26;3:
pubmed: 24683445
Science. 2010 Sep 17;329(5998):1537-41
pubmed: 20847275
PLoS One. 2013;8(1):e48814
pubmed: 23382797
Sci Rep. 2016 Mar 02;6:22519
pubmed: 26931825
Cancer Cell. 2014 Apr 14;25(4):501-15
pubmed: 24735924
Neuropsychopharmacology. 2008 Jan;33(1):110-33
pubmed: 17912251
Neurotox Res. 2017 Jul;32(1):82-93
pubmed: 28321582
Oncol Rep. 2016 Nov;36(5):2535-2543
pubmed: 27599779
Genes (Basel). 2017 Sep 22;8(10):
pubmed: 28937658
Nat Med. 2016 Mar;22(3):238-49
pubmed: 26937618
Neuro Endocrinol Lett. 2008 Jun;29(3):287-91
pubmed: 18580840
Innov Clin Neurosci. 2017 Feb 01;14(1-2):53-55
pubmed: 28386521
Biomed Res Int. 2018 Jul 26;2018:3634563
pubmed: 30148165
J Neuroinflammation. 2013 Apr 01;10:43
pubmed: 23547920
Mol Cell Proteomics. 2013 Feb;12(2):343-55
pubmed: 23161513
Biol Psychiatry. 2006 May 15;59(10):929-39
pubmed: 16427028
J Psychiatr Res. 2011 Jan;45(1):92-5
pubmed: 20546789
Mol Cell Neurosci. 2006 Apr;31(4):642-8
pubmed: 16446100
AIDS. 2017 Sep 10;31(14):F9-F17
pubmed: 28692534
Nat Neurosci. 2013 Apr;16(4):464-72
pubmed: 23502536
Sci Rep. 2015 Jan 23;5:7989
pubmed: 25612542
Front Neurosci. 2017 May 22;11:278
pubmed: 28588440
Sci Rep. 2017 Aug 30;7(1):9954
pubmed: 28855621
Adv Clin Chem. 2016;74:103-41
pubmed: 27117662
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
J Vis Exp. 2014 Oct 19;(92):e51623
pubmed: 25350417
Gynecol Oncol. 2008 Jul;110(1):13-21
pubmed: 18589210
Proteomics Clin Appl. 2007 Nov;1(11):1446-61
pubmed: 21136642
Front Physiol. 2012 May 28;3:145
pubmed: 22654762
Mol Ther. 2011 Oct;19(10):1769-79
pubmed: 21915101
Glia. 2015 Apr;63(4):626-34
pubmed: 25451814
Nucleic Acids Res. 2014 Aug;42(14):9195-208
pubmed: 25053844
Nat Neurosci. 2017 Dec;20(12):1752-1760
pubmed: 29184215
Curr Pharm Des. 2014;20(10):1422-49
pubmed: 23789948
J Comp Neurol. 2009 Jun 20;514(6):641-57
pubmed: 19363811
Oncotarget. 2017 Feb 28;8(9):14395-14407
pubmed: 28122335
Clin Chem. 2018 Oct;64(10):1463-1473
pubmed: 30021922
Hum Mol Genet. 2012 Oct 15;21(R1):R125-34
pubmed: 22872698
Sci Rep. 2017 Aug 29;7(1):9574
pubmed: 28851955
Brain Inj. 2018;32(10):1277-1284
pubmed: 29913077
J Extracell Vesicles. 2014 Nov 13;3:24722
pubmed: 25398455
Mol Brain. 2017 Jun 24;10(1):28
pubmed: 28646910
Cell Mol Bioeng. 2016 Dec;9(4):509-529
pubmed: 28392840
PLoS Biol. 2013 Jul;11(7):e1001604
pubmed: 23874151
Am J Psychiatry. 2006 Nov;163(11):1905-17
pubmed: 17074942
Mol Cell Neurosci. 2011 Feb;46(2):409-18
pubmed: 21111824
Acta Neuropathol. 2014 Nov;128(5):639-650
pubmed: 24997849
Biol Psychiatry. 2011 Mar 15;69(6):526-33
pubmed: 21168126
PLoS One. 2014 Jan 27;9(1):e86469
pubmed: 24475125
Theranostics. 2017 Jan 26;7(3):789-804
pubmed: 28255367
Front Physiol. 2012 Apr 30;3:119
pubmed: 22557979
Front Cell Neurosci. 2016 Jan 19;9:501
pubmed: 26834560
Pharmacogenomics. 2015;16(5):541-53
pubmed: 25916524
J Cell Biol. 2003 May 12;161(3):653-60
pubmed: 12743111
Int J Mol Sci. 2017 Aug 03;18(8):
pubmed: 28771182
Cell Logist. 2012 Oct 1;2(4):203-208
pubmed: 23538558
Pharm Res. 2015 Jun;32(6):2003-14
pubmed: 25609010
Front Pharmacol. 2018 Sep 26;9:1116
pubmed: 30319428
Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11172-7
pubmed: 16837572
Stem Cells Int. 2017;2017:1719050
pubmed: 29081809