Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging.
Aged
Aged, 80 and over
Aging
Alzheimer Disease
/ diagnosis
Amyloid beta-Peptides
/ analysis
Anxiety
/ diagnosis
Brain
/ diagnostic imaging
Cognitive Dysfunction
/ diagnosis
Cross-Sectional Studies
Depression
/ diagnosis
Female
Humans
Logistic Models
Male
Middle Aged
Neuropsychological Tests
Positron-Emission Tomography
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
28 03 2019
28 03 2019
Historique:
received:
11
02
2019
accepted:
16
02
2019
entrez:
30
3
2019
pubmed:
30
3
2019
medline:
10
1
2020
Statut:
epublish
Résumé
Neuropsychiatric symptoms (NPS) are a risk factor for cognitive impairment and are associated with cortical β-amyloid (Aβ) deposition. We conducted a cross-sectional study derived from the ongoing population-based Mayo Clinic Study of Aging to examine the frequency of NPS among cognitively unimpaired (CU) and mild cognitive impairment (MCI) participants who either have normal (A-) or abnormal (A+) Aβ deposition. We also investigated whether combined presence of MCI and amyloid positivity (MCI/A+) is associated with greater odds of having NPS as compared to CU/A- (defined as reference group). Participants were 1627 CU and MCI individuals aged ≥ 50 years (54% males; median age 73 years). All participants underwent NPS assessment (Neuropsychiatric Inventory Questionnaire (NPI-Q); Beck Depression Inventory II (BDI-II); Beck Anxiety Inventory (BAI)) and
Identifiants
pubmed: 30923322
doi: 10.1038/s41398-019-0456-z
pii: 10.1038/s41398-019-0456-z
pmc: PMC6438979
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
123Subventions
Organisme : NIMH NIH HHS
ID : K01 MH068351
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG041851
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG011378
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG028573
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057708
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
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