Harnessing the mesenchymal stem cell secretome for regenerative urology.
Journal
Nature reviews. Urology
ISSN: 1759-4820
Titre abrégé: Nat Rev Urol
Pays: England
ID NLM: 101500082
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
pubmed:
30
3
2019
medline:
31
1
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
The extensive arsenal of bioactive molecules secreted by mesenchymal stem cells (MSCs), known as the secretome, has demonstrated considerable therapeutic benefit in regenerative medicine. Investigation into the therapeutic potential of the secretome has enabled researchers to replicate the anti-inflammatory, pro-angiogenic and trophic effects of stem cells without the need for the cells themselves. Furthermore, treatment with the MSC secretome could circumvent hurdles associated with cellular therapy, including oncogenic transformation, immunoreactivity and cost. Thus, a clear rationale exists for investigating the therapeutic potential of the MSC secretome in regenerative urology. Indeed, preclinical studies have demonstrated the therapeutic benefits of the MSC secretome in models of stress urinary incontinence, renal disease, bladder dysfunction and erectile dysfunction. However, the specific mechanisms underpinning therapeutic activity are unclear and require further research before clinical translation. Improvements in current proteomic methods used to characterize the secretome will be necessary to provide further insight into stem cells and their secretome in regenerative urology.
Identifiants
pubmed: 30923338
doi: 10.1038/s41585-019-0169-3
pii: 10.1038/s41585-019-0169-3
pmc: PMC7027199
mid: NIHMS1057114
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-375Subventions
Organisme : Intramural VA
ID : F9261-L
Pays : United States
Organisme : RRD VA
ID : I01 RX000228
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD059859
Pays : United States
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