Stage IV lung carcinoids: spectrum and evolution of proliferation rate, focusing on variants with elevated proliferation indices.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Carcinoid Tumor
/ chemistry
Cell Proliferation
Diagnosis, Differential
Disease Progression
Female
Humans
Ki-67 Antigen
/ analysis
Lung Neoplasms
/ chemistry
Male
Middle Aged
Mitosis
Mitotic Index
Neoplasm Staging
Neuroendocrine Tumors
/ chemistry
Predictive Value of Tests
Journal
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
ISSN: 1530-0285
Titre abrégé: Mod Pathol
Pays: United States
ID NLM: 8806605
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
29
09
2018
accepted:
21
02
2019
revised:
21
02
2019
pubmed:
30
3
2019
medline:
28
4
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
The spectrum and evolution of proliferation rates in stage IV lung carcinoids is poorly defined. In particular, there are limited data on the prevalence and characteristics of tumors exceeding the standard upper proliferative criteria-as defined largely based on early-stage carcinoids-in metastatic setting. Sixty-six patients with stage IV lung carcinoids were identified, and all evaluable samples (n = 132; mean 2 samples per patient) were analyzed for mitotic counts and Ki-67 rate. Clinicopathologic and genomic features associated with elevated proliferation rates (>10 mitoses per 2 mm
Identifiants
pubmed: 30923345
doi: 10.1038/s41379-019-0248-2
pii: S0893-3952(22)01028-6
pmc: PMC6746332
mid: NIHMS1522409
doi:
Substances chimiques
Biomarkers, Tumor
0
Ki-67 Antigen
0
MKI67 protein, human
0
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1106-1122Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
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