Endothelin-1/nitric oxide balance and HOMA index in children with excess weight and hypertension: a pathophysiological model of hypertension.
Blood pressure
Children
Endothelin
Excess weight
Nitric oxide
Journal
Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
01
2019
accepted:
05
03
2019
revised:
05
03
2019
pubmed:
30
3
2019
medline:
23
9
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
The aim of this study was to investigate the relationship between endothelin-1, nitric oxide, insulin resistance, and blood pressure in young subjects with a high prevalence of excess weight and/or elevated blood pressure. In a cohort of 238 children (mean age = 11.1 years), height, weight, waist circumference, and blood pressure were assessed. Body mass index, waist-to-height ratio, and blood pressure percentiles were calculated, and the children were classified as having excess weight and elevated blood pressure according to the International Obesity Task Force and the US blood pressure nomograms specific for gender, age and height, respectively. Endothelin-1 and nitric oxide production were assessed, and the homeostatic model assessment index was calculated. Forty-three percent of children were male, 71% had excess weight, and 37% had systolic and/or diastolic values above the ninetieth percentile. Plasma endothelin-1 and nitric oxide production were independently correlated (p < 0.05). In multivariate analyses, the HOMA index was associated with systolic and diastolic blood pressure (p = 0.01), and nitric oxide was independently related to diastolic blood pressure (p = 0.04), even after adjustment for measures of body composition. By using the waist-to-height ratio instead of BMI in the statistical model, the association between the homeostatic model assessment index and blood pressure was attenuated, while the results remained similar for nitric oxide. No correlation was found between endothelin-1 and blood pressure. In our study population, the correlation between nitric oxide and blood pressure and the lack of a relationship between endothelin-1 and blood pressure could be explained by an increase in the vasodilator effect of local and systemic nitric oxide, which counteracts the possible hypertensive effect of endothelin-1.
Identifiants
pubmed: 30923371
doi: 10.1038/s41440-019-0253-3
pii: 10.1038/s41440-019-0253-3
doi:
Substances chimiques
Endothelin-1
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1192-1199Références
Barton M, Yanagisawa M. Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol. 2008;86:498.
doi: 10.1139/Y08-059
Chen M, Todd-Turla K, Wang WH, Cao X, Smart A, Brosius FC et al. Endothelin-1 mRNA in glomerular and epithelial cells of kidney. Am J Physiol Ren Fluid Electrolyte Physiol. 1993;265:F542–50.
doi: 10.1152/ajprenal.1993.265.4.F542
Levin ER. Endothelins. N Engl J Med. 1995;333:356–63.
doi: 10.1056/NEJM199508103330607
Ujiie K, Terada Y, Nonoguchi H, Shinohara M, Tomita K, Marumo F. Messenger RNA expression and synthesis of endothelin-1 along rat nephron segments. J Clin Invest. 1992;90:1043–8.
doi: 10.1172/JCI115918
Hexum TD, Hoeger C, Rivier JE, Baird A, Brown MR. Characterization of endothelin secretion by vascular endothelial cells. Biochem Res Commun. 1990;167:294–300.
doi: 10.1016/0006-291X(90)91764-J
Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomans HA, Rabelink TJ et al. Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. Circulation. 1998;97:752–6.
doi: 10.1161/01.CIR.97.8.752
Rakugi H, Nakamaru M, Tabuchi Y, Nagano M, Mikami H, Ogihara T. Endothelin stimulates the release of prostacyclin from rat mesenteric arteries. Biochem Res Commun. 1989;160:924–8.
doi: 10.1016/0006-291X(89)92523-0
Warner TD, Mitchell JA, de Nucci G, Vane JR. Endothelin-1 and endothelin-3 release EDRF from isolated perfused arterial vessels of the rat and rabbit. J Cardiovasc. 1989;13 Suppl 5:S85–8.
de Nucci G, Thomas R, D’Orleans-Juste P, Antunes E, Walder C, Warner TD. et al. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci USA. 1988;85:9797–800.
doi: 10.1073/pnas.85.24.9797
Bourque SL, Davidge ST, Adams MA. The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives. Am J Physiol Regul Integr Comp Physiol. 2011;300:R1288–95.
doi: 10.1152/ajpregu.00397.2010
Ferrannini E, Natali A, Bell P, Cavallo-Perin P, Lalic N, Mingrone G. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J ClinInvest. 1997;100:1166–73.
Ferri C, Pittoni V, Piccoli A, Laurenti O, Cassone MR, Bellini C et al. Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo. J Clin Endocrinol Metab. 1995;80:829–35.
pubmed: 7883838
Hu RM, Levin ER, Pedram A, Frank HJ. Insulin stimulates production and secretion of endothelin from bovine endothelial cells. Diabetes. 1993;42:351–8.
doi: 10.2337/diab.42.2.351
Lteif AA, Fulford AD, Considine RV, Gelfand I, Baron AD, Mather KJ. Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans. Am J Physiol Endocrinol Metab. 2008;295:E1510–7.
doi: 10.1152/ajpendo.90549.2008
Mahmoud AM, Szczurek MR, Blackburn BK, Mey JT, Chen Z, Robinson AT et al. Hyperinsulinemia augments endothelin-1 protein expression and impairs vasodilation of human skeletal muscle arterioles. Physiol Rep. 2016;4:e12895.
doi: 10.14814/phy2.12895
Weil BR, Westby CM, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Enhanced endothelin-1 system activity with overweight and obesity. Am J Physiol Heart Circ Physiol. 2011;301:H689–695. https://doi.org/10.1152/ajpheart.00206.2011
doi: 10.1152/ajpheart.00206.2011
pubmed: 21666117
pmcid: 3191085
Stryer L. Biochemestry. 4th edn. Freeman and Company: New York, 1995.
Black SM, Fineman JR. Oxidative and nitrosative stress in pediatric pulmonary hypertension: roles of endothelin-1 and nitric oxide. Vascul Pharmacol. 2006;45:308–16.
doi: 10.1016/j.vph.2006.08.005
Pollock JS, Pollock DM. Endothelin and NOS1/nitric oxide signaling and regulation of sodium homeostasis. Curr Opin Nephrol Hypertens. 2008;17:70–5.
doi: 10.1097/MNH.0b013e3282f34b02
Haynes WG, Noon JP, Walker BR, Webb DJ. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens. 1993;11:1375–80.
doi: 10.1097/00004872-199312000-00009
Wolzt M, Schmetterer L, Ferber W, Artner E, Mensik C, Eichler HG et al. Effect of nitric oxide synthase inhibition on renal hemodynamics in humans: reversal by L-arginine. Am J Physiol Ren Fluid Electrolyte Physiol. 1997;272:F178–82.
doi: 10.1152/ajprenal.1997.272.2.F178
Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. Brit Med J. 2000;320:1240–3.
doi: 10.1136/bmj.320.7244.1240
National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114 2 Suppl 4th Report:555–76.
Oberfield SE, Levine LS, Firpo A, Lawrence D Sr., Stoner E, Levy DJ et al. Primary hyperaldosteronism in childhood due to unilateral macronodular hyperplasia. Case report. Hypertension. 1984;6:75–84.
doi: 10.1161/01.HYP.6.1.75
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.
doi: 10.1007/BF00280883
Orlando A, Re F, Sesana S, Rivolta I, Panariti A, Brambilla D et al. CazzanigaE.Effect of nanoparticles binding β-amyloid peptide on nitric oxide production by cultured endothelial cells and macrophages. Int J Nanomed. 2013;8:1335–47.
doi: 10.2217/nnm.13.108
Schiffrin EL. Vascular endothelin in hypertension. Vascul Pharmacol. 2005;43:19–29.
doi: 10.1016/j.vph.2005.03.004
Goch A, Banach M, Mikhailidis DP, Rysz J, Goch JH. Endothelial dysfunction in patients with noncomplicated and complicated hypertension. Clin Exp Hypertens. 2009;31:20–30.
doi: 10.1080/10641960802409846
Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R et al. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature. 1994;368:703–10.
doi: 10.1038/368703a0
Saito Y, Nakao K, Mukoyama M, Shirakami G, Itoh H, Yamada T et al. Application of monoclonal antibodiesfor endothelin to hypertensive research. Hypertension. 1990;15:734–8.
doi: 10.1161/01.HYP.15.6.734
Fernandez-Cruz A, Martin P, Fernandez L, Sanchez J, Ibarra J, Moya J et al. Plasma endothelin is increased in young essential hypertensives but not in elderly essential or diabetic hypertensives. J Hypertens. 1993;11 suppl. 5:S146–147.
Lemne CE, Lundeberg T, Theodorsson E, de Faire U. Increased basal concentrations of plasma endothelin in borderline hypertension. J Hypertens. 1994;12:1069–74.
doi: 10.1097/00004872-199409000-00012
Veglio F, Bertello P, Pinna G, Mulatero P, Rossi A, Gurioli L et al. Plasma endothelin in essentialhypertension and diabetesmellitus. J Hum Hypertens. 1993;7:321–5.
pubmed: 8410922
Davenport AP, Ashby MJ, Easton P, Ella S, Bedford J, Dickerson C et al. A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects. Clin Sci. 1990;78:261–4.
doi: 10.1042/cs0780261
Sorensen SS, Egeblad M, Eiskjaer H, Madsen B, Nielsen CB, Sihm I et al. Endothelin in renovascular and essential hypertension. Blood Press. 1994;3:364–9.
doi: 10.3109/08037059409102288
Saito Y, Nakao K, Mukoyama M, Imura H. Increased plasma endothelin level in patients with essentialhypertension. New Engl J Med. 1990;322:205.
pubmed: 2403657
Naruse M, Kawana M, Hifumi S, Naruse K, Yoshihara I, Oka T et al. Plasma immunoreactiveendothelin,but not thrombomodulin, is increased in patients with essential hypertension and ischemic heart disease. J Cardiovasc Pharmacol. 1991;17 suppl. 7:S471–474.
doi: 10.1097/00005344-199100177-00135
Widimsky J Jr., Horky K, Dvorakova J. Plasma endothelin-1,2 levels in mild and severe hypertension. J Hypertens. 1991;9 suppl. 6:S194–195.
Aflyatumova GN, Nigmatullina RR, Sadykova DI, Chibireva MD, Fugetto F, Serra R. Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents. Vasc Health Risk Manag. 2018;14:213–23.
doi: 10.2147/VHRM.S170317
Paravicini TM, Touyz RM. Redox signaling in hypertension. Cardiovasc Res. 2006;71:247–58.
doi: 10.1016/j.cardiores.2006.05.001
Strambi M, Messa G, Berni S, Capitani S, Pammolli A, Iacoponi F et al. Basal and post-ischemic vascular compliance in children/adolescents born small for gestational age. Pediatr Nephrol. 2012;27:1541–6.
doi: 10.1007/s00467-012-2168-y
Katona E, Settakis G, Varga Z, Paragh G, Bereczki D, Fülesdi B et al. Target-organ damage in adolescent hypertension. Analysis of potential influencing factors, especially nitric oxide and endothelin-1. J Neurol Sci. 2006;247:138–43.
doi: 10.1016/j.jns.2006.04.007
Genovesi S, Antolini L, Giussani M, Brambilla P, Barbieri V, Galbiati S et al. Hypertension, prehypertension, and transient elevated blood pressure in children: association with weight excess and waist circumference. Am J Hypertens. 2010;23:756–61.
doi: 10.1038/ajh.2010.50
Genovesi S, Antolini L, Giussani M, Pieruzzi F, Galbiati S, Valsecchi MG et al. Usefulness of waist circumference for the identification of childhood hypertension. J Hypertens. 2008;26:1563–70.
doi: 10.1097/HJH.0b013e328302842b
Cardillo C, Campia U, Iantorno M, Panza JA. Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. Hypertension. 2004;43:36–40.
doi: 10.1161/01.HYP.0000103868.45064.81
Mather KJ, Mirzamohammadi B, Lteif A, Steinberg HO, Baron AD. Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes. Diabetes. 2002;51:3517–23.
doi: 10.2337/diabetes.51.12.3517
Charakida M, Jones A, Falaschetti E, Khan T, Finer N, Sattar N et al. Childhood obesity and vascular phenotypes: a population study. J Am Coll Cardiol. 2012;60:2643–50.
doi: 10.1016/j.jacc.2012.08.1017
Cardillo C, Kilcoyne CM, Waclawiw M, Cannon RO 3rd, Panza JA. Role of endothelin in the increased vascular tone of patients with essential hypertension. Hypertension. 1999;33:753–8.
doi: 10.1161/01.HYP.33.2.753