Netrin Family: Role for Protein Isoforms in Cancer.


Journal

Journal of nucleic acids
ISSN: 2090-0201
Titre abrégé: J Nucleic Acids
Pays: United States
ID NLM: 101533042

Informations de publication

Date de publication:
2019
Historique:
received: 07 12 2018
accepted: 06 02 2019
entrez: 30 3 2019
pubmed: 30 3 2019
medline: 30 3 2019
Statut: epublish

Résumé

Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are translated and regulated by alternative splicing. We review here the diversity of isoforms of the netrin family members and their known and potential roles in cancer.

Identifiants

pubmed: 30923634
doi: 10.1155/2019/3947123
pmc: PMC6408995
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

3947123

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Auteurs

Caroline Suzanne Bruikman (CS)

Amsterdam UMC, University of Amsterdam, Department of Vascular Medicine, Location Meibergdreef, Amsterdam, Netherlands.

Huayu Zhang (H)

Leiden University Medical Center, Department of Internal Medicine, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, Netherlands.

Anneli Maite Kemper (AM)

Leiden University Medical Center, Department of Internal Medicine, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, Netherlands.

Janine Maria van Gils (JM)

Leiden University Medical Center, Department of Internal Medicine, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, Netherlands.

Classifications MeSH