Validation of two parent-reported autism spectrum disorders screening tools M-CHAT-R and SCQ in Bamako, Mali.
AMALDEME, Malian association for mental deficiencies
ASD, Autism spectrum disorders
AUC, Area under the Curve
CHU, University hospital centers
CSCOM, Community health centers
CSRef, District health centers
DNS, National direction of health
DRS, Regional direction of health
DSM-V, Diagnostic and Statistical Manual of Mental Disorders
FAPH, Faculty of Pharmacy
FMOS, Faculty of medicine and odonto-stomatology
ICD-10, International Statistical Classification of Diseases and Related Health Problems-10
LR+, Positive likelihood
LR-, Negative likelihood
M-CHAT-R
M-CHAT-R, Modified checklist for autism in toddlers-Revised
M-CHAT-R/F, Modified checklist for autism in toddlers-Revised/Follow up
Mali
NPV
NPV, Negative predictive value
PPV
PPV, Positive predictive value
SCQ
SCQ, Social communication questionnaire
USTTB, University of Sciences, Techniques and Technologies of Bamako
Journal
eNeurologicalSci
ISSN: 2405-6502
Titre abrégé: eNeurologicalSci
Pays: Netherlands
ID NLM: 101667077
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
07
03
2019
accepted:
09
03
2019
entrez:
30
3
2019
pubmed:
30
3
2019
medline:
30
3
2019
Statut:
epublish
Résumé
Early screening is crucial for early autism spectrum disorders (ASD) diagnosis and intervention. ASD screening tools have mostly been constructed based on the Western cultural context. We hypothesized that their use in Mali may require a prior validation. To validate the modified checklist for autism in toddlers-Revised (M-CHAT-R) and the social communication questionnaire (SCQ) in the Malian sociocultural context for ASD screening. We administered M-CHAT-R and SCQ in 947 toddlers aged 16-30 months old at the district and community health centers in Bamako and 120 patients (60 autistic and 60 age and sex matched controls) aged ≥4 years old at the psychiatry department in Bamako. Toddlers at moderate to high risk of ASD underwent M-CHAT-R/F and clinical evaluation by an ASD multidisciplinary team. M-CHAT-R and SCQ were evaluated for cultural appropriateness by Malian anthropologists. The sensitivity, specificity, PPV, NPV were determined for both M-CHAT-R and SCQ. Health professionals have been trained during ASD seminary on how to use M-CHAT-R and SCQ for ASD screening in Bamako. We found for the M-CHAT-R a sensitivity of 50%, a specificity of 100%, a PPV of 100% and a NPV of 87%. The SCQ had a sensitivity of 71%, a specificity of 72%, a PPV of 73% and a NPV of 70%. We have found four out of 20 items on the M-CHAT-R that were culturally inappropriate in the Malian context. M-CHAT-R and SCQ can be used for early autism screening in Mali. In the future, we plan to train a descent number of Malian physicians in chief and pediatricians at the district hospitals across the country to integrate the early ASD screening into the national health system. M-CHAT-R has a perfect specificity and SCQ a fair diagnostic accuracy for ASD in Mali.
Sections du résumé
BACKGROUND
BACKGROUND
Early screening is crucial for early autism spectrum disorders (ASD) diagnosis and intervention. ASD screening tools have mostly been constructed based on the Western cultural context. We hypothesized that their use in Mali may require a prior validation.
OBJECTIVE
OBJECTIVE
To validate the modified checklist for autism in toddlers-Revised (M-CHAT-R) and the social communication questionnaire (SCQ) in the Malian sociocultural context for ASD screening.
STUDY DESIGN
METHODS
We administered M-CHAT-R and SCQ in 947 toddlers aged 16-30 months old at the district and community health centers in Bamako and 120 patients (60 autistic and 60 age and sex matched controls) aged ≥4 years old at the psychiatry department in Bamako. Toddlers at moderate to high risk of ASD underwent M-CHAT-R/F and clinical evaluation by an ASD multidisciplinary team. M-CHAT-R and SCQ were evaluated for cultural appropriateness by Malian anthropologists. The sensitivity, specificity, PPV, NPV were determined for both M-CHAT-R and SCQ. Health professionals have been trained during ASD seminary on how to use M-CHAT-R and SCQ for ASD screening in Bamako.
RESULTS
RESULTS
We found for the M-CHAT-R a sensitivity of 50%, a specificity of 100%, a PPV of 100% and a NPV of 87%. The SCQ had a sensitivity of 71%, a specificity of 72%, a PPV of 73% and a NPV of 70%. We have found four out of 20 items on the M-CHAT-R that were culturally inappropriate in the Malian context.
DISCUSSION
CONCLUSIONS
M-CHAT-R and SCQ can be used for early autism screening in Mali. In the future, we plan to train a descent number of Malian physicians in chief and pediatricians at the district hospitals across the country to integrate the early ASD screening into the national health system.
CONCLUSION
CONCLUSIONS
M-CHAT-R has a perfect specificity and SCQ a fair diagnostic accuracy for ASD in Mali.
Identifiants
pubmed: 30923752
doi: 10.1016/j.ensci.2019.100188
pii: S2405-6502(19)30012-7
pii: 100188
pmc: PMC6423411
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100188Références
Cancer. 1950 Jan;3(1):32-5
pubmed: 15405679
J Autism Dev Disord. 2015 May;45(5):1271-80
pubmed: 25348175
Neurooncol Pract. 2015 Dec;2(4):162-166
pubmed: 31386059
Afr J Psychiatry (Johannesbg). 2011 Jul;14(3):208-10
pubmed: 21863205
J Autism Dev Disord. 2006 Oct;36(7):839-47
pubmed: 16897398
EJIFCC. 2009 Jan 20;19(4):203-11
pubmed: 27683318
Forensic Sci Int. 2017 Jul;276:142-153
pubmed: 27181589
Br J Psychiatry. 1999 Nov;175:444-51
pubmed: 10789276
Dev Med Child Neurol. 2014 Nov;56(11):1038-9
pubmed: 24954005
Autism Res. 2012 Jun;5(3):160-79
pubmed: 22495912