SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism.
cancer
fluorescence
imaging agents
metabolites
super-resolution imaging
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
20 05 2019
20 05 2019
Historique:
received:
12
01
2019
pubmed:
30
3
2019
medline:
9
9
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small-sized multi-colored fluorophores for real-time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.
Identifiants
pubmed: 30924239
doi: 10.1002/anie.201900465
pmc: PMC6563150
doi:
Substances chimiques
Fluorescent Dyes
0
Ionophores
0
Green Fluorescent Proteins
147336-22-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6911-6915Subventions
Organisme : Wellcome Trust
ID : 100104/Z/12/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M025160/1
Pays : United Kingdom
Organisme : OPTIMA
ID : EP/L016559/1
Pays : International
Organisme : MSCA Fellowship
ID : 704912
Pays : International
Organisme : Medical Research Scotland
ID : 879-2015
Pays : International
Organisme : Royal Society
ID : IEC\R3\170132
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : CTQ2017-85378-R
Pays : International
Organisme : European Research Council
ID : 771443
Pays : International
Informations de copyright
© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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