VU0810464, a non-urea G protein-gated inwardly rectifying K
Animals
Anxiety
/ physiopathology
Behavior, Animal
/ drug effects
Brain
/ cytology
Cells, Cultured
Female
Fever
/ etiology
G Protein-Coupled Inwardly-Rectifying Potassium Channels
/ physiology
Male
Mice, Inbred C57BL
Mice, Transgenic
Neurons
/ drug effects
Sinoatrial Node
/ cytology
Stress, Psychological
/ complications
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
04
09
2018
revised:
16
02
2019
accepted:
20
02
2019
pubmed:
30
3
2019
medline:
1
9
2020
entrez:
30
3
2019
Statut:
ppublish
Résumé
G protein-gated inwardly rectifying K We used whole-cell electrophysiology to measure the efficacy and potency of VU0810464 in neurons and the selectivity of VU0810464 for neuronal and cardiac K VU0810464 and ML297 exhibited comparable efficacy and potency as neuronal K VU0810464 represents a new class of K
Sections du résumé
BACKGROUND AND PURPOSE
G protein-gated inwardly rectifying K
EXPERIMENTAL APPROACH
We used whole-cell electrophysiology to measure the efficacy and potency of VU0810464 in neurons and the selectivity of VU0810464 for neuronal and cardiac K
KEY RESULTS
VU0810464 and ML297 exhibited comparable efficacy and potency as neuronal K
CONCLUSION AND IMPLICATIONS
VU0810464 represents a new class of K
Identifiants
pubmed: 30924523
doi: 10.1111/bph.14671
pmc: PMC6555862
doi:
Substances chimiques
G Protein-Coupled Inwardly-Rectifying Potassium Channels
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2238-2249Subventions
Organisme : NIMHD NIH HHS
ID : U54 MD007586
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107399
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105550
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL139090
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA034696
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM059994
Pays : United States
Organisme : NIH HHS
ID : S10 OD021734
Pays : United States
Informations de copyright
© 2019 The British Pharmacological Society.
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