Impact of sarcopenia on diaphragm muscle fatigue.

Aging / pathology Animals Diaphragm / pathology Female Male Muscle Fatigue / physiology Rats Rats, Inbred F344 Sarcopenia / pathology
fibre type sarcopenia specific force

Journal

Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940

Informations de publication

Date de publication:
07 2019
Historique:
received: 21 12 2018
accepted: 26 03 2019
pubmed: 30 3 2019
medline: 8 8 2020
entrez: 30 3 2019
Statut: ppublish

Résumé

What is the central question of this study? Is the residual force generated by the diaphragm muscle after repeated activation reduced with sarcopenia, and is the residual force generated after fatiguing activation sufficient to sustain ventilatory behaviours of diaphragm muscle in young and old rats? What is the main finding and its importance? After diaphragm muscle fatigue, the residual specific force after 120 s of repeated stimulation was unaffected by ageing and was sufficient to accomplish ventilatory behaviours, but not expulsive manoeuvres (e.g. coughing). The inability to perform expulsive behaviours might underlie the increased susceptibility of older individuals to respiratory tract infections. Type IIx and/or IIb diaphragm muscle (DIAm) fibres make up more fatigable motor units that are more vulnerable to sarcopenia, i.e. age-associated reductions of specific force and cross-sectional area. In contrast, type I and IIa DIAm fibres form fatigue-resistant motor units that are relatively unchanged with age. The fatigue resistance of the DIAm is assessed by normalizing the residual force generated after a period of repeated supramaximal stimulation (e.g. 120 s) to the initial maximal force. Given that sarcopenia primarily affects more fatigable DIAm motor units, apparent fatigue resistance improves with ageing. However, the central question is whether there is an ageing-related difference in the residual force generated by the DIAm after repeated stimulation and whether this force is sufficient to sustain ventilatory behaviours of DIAm. In 6- and 24-month-old Fischer 344 rats, we assessed the loss of ex vivo DIAm force throughout 120 s of repeated supramaximal stimulation at 10, 40 and 75 Hz. We found that relative fatigue resistance improved in older rats at 40 and 75 Hz stimulation. Across all stimulation frequencies, DIAm residual force was unchanged with age (∼5 N cm

Identifiants

DOI: 10.1113/EP087558 PMID: 30924589 PMC: PMC6602803
pubmed: 30924589
doi: 10.1113/EP087558
pmc: PMC6602803
mid: NIHMS1020591
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1090-1099

Subventions

Organisme : NIA NIH HHS
ID : R01 AG044615
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057052
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146114
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2019 The Authors. Experimental Physiology © 2019 The Physiological Society.

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Auteurs

Matthew J Fogarty (MJ)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Carlos B Mantilla (CB)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Gary C Sieck (GC)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0003-3040-9424

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Impact of sarcopenia on diaphragm muscle fatigue.
questionsmedicales.fr › Eucaryotes › Animaux › Impact of sarcopenia on diaphragm muscle fatigue.
questionsmedicales.fr › Appareil locomoteur › Muscles respiratoires › Muscle diaphragme › Impact of sarcopenia on diaphragm muscle fatigue.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Fatigue musculaire › Impact of sarcopenia on diaphragm muscle fatigue.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Impact of sarcopenia on diaphragm muscle fatigue.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée F344 › Impact of sarcopenia on diaphragm muscle fatigue.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Sarcopénie › Impact of sarcopenia on diaphragm muscle fatigue.