NBE-Controlled Palladium-Catalyzed Interannular Selective C-H Silylation: Access to Divergent Silicon-Containing 1,1'-Biaryl-2-Acetamides.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
19 04 2019
19 04 2019
Historique:
pubmed:
30
3
2019
medline:
30
3
2019
entrez:
30
3
2019
Statut:
ppublish
Résumé
A novel palladium-catalyzed interannular selective C-H silylation of 1,1'-biaryl-2-acetamides is described. The combination of palladium catalyst with copper oxidant enables meta- or ortho-selective C-H silylation by employing hexamethyldisilane as a trimethylsilyl source, which relies on the control of NBE derivatives as a switch, thus providing straightforward access to divergent silicon-containing 1,1'-biaryl-2-acetamides.
Identifiants
pubmed: 30924667
doi: 10.1021/acs.orglett.9b00690
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng