Diverse flavonoids from the roots of Millettia brandisiana.
Antiaromatase
Cytotoxicity
Fabaceae
Flavonoids
Millettia brandisiana
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
10
08
2018
revised:
18
03
2019
accepted:
18
03
2019
pubmed:
30
3
2019
medline:
17
5
2019
entrez:
30
3
2019
Statut:
ppublish
Résumé
The phytochemical investigation for the constituents of the roots of Millettia brandisiana, using bioassay guided fractionation, resulted in the isolation of five previously undescribed (namely brandisianones A-E) and twenty-six known flavonoids. Their chemical structures were determined using a combination of NMR, MS, IR, optical rotation and CD analysis, as well as comparison with the literature data. The crude extract as well as the isolated compounds were evaluated in various biological assays for their cytotoxicity against a panel of human cancer cell lines, potential inhibitory activity against aromatase, and antioxidant property using the oxygen radical absorbance capacity (ORAC) with an aim to search for leads and develop them to drug candidates in our drug discovery effort, we identified three bioactive flavonoids from M. brandisiana which could be further developed into a potential chemopreventive (antiaromatase) agent against breast cancer.
Identifiants
pubmed: 30925376
pii: S0031-9422(18)30446-1
doi: 10.1016/j.phytochem.2019.03.013
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Flavonoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
157-164Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.