PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?
PTEN
biomarkers
personalized cancer therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
28 Mar 2019
28 Mar 2019
Historique:
received:
28
02
2019
revised:
22
03
2019
accepted:
25
03
2019
entrez:
31
3
2019
pubmed:
31
3
2019
medline:
31
3
2019
Statut:
epublish
Résumé
Identifying putative biomarkers of clinical outcomes in cancer is crucial for successful enrichment, and for the selection of patients who are the most likely to benefit from a specific therapeutic approach. Indeed, current research in personalized cancer therapy focuses on the possibility of identifying biomarkers that predict prognosis, sensitivity or resistance to therapies. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor gene that regulates several crucial cell functions such as proliferation, survival, genomic stability and cell motility through both enzymatic and non-enzymatic activities and phosphatidylinositol 3-kinase (PI3K)-dependent and -independent mechanisms. Despite its undisputed role as a tumor suppressor, assessment of PTEN status in sporadic human tumors has yet to provide clinically robust prognostic, predictive or therapeutic information. This is possibly due to the exceptionally complex regulation of PTEN function, which involves genetic, transcriptional, post-transcriptional and post-translational events. This review shows a brief summary of the regulation and function of PTEN and discusses its controversial aspects as a prognostic/predictive biomarker.
Identifiants
pubmed: 30925702
pii: cancers11040435
doi: 10.3390/cancers11040435
pmc: PMC6520939
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 18622
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 22312
Références
Int J Oncol. 1999 Sep;15(3):547-53
pubmed: 10427138
J Natl Cancer Inst. 1999 Nov 3;91(21):1820-8
pubmed: 10547389
Cell. 1999 Oct 29;99(3):323-34
pubmed: 10555148
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4233-8
pubmed: 10760291
J Natl Cancer Inst. 2000 Jun 7;92(11):924-30
pubmed: 10841828
Mol Cell Biol. 2000 Jul;20(14):5010-8
pubmed: 10866658
Hum Mutat. 2000;16(2):109-22
pubmed: 10923032
J Biol Chem. 2001 Jan 12;276(2):993-8
pubmed: 11035045
Am J Pathol. 2001 Jul;159(1):359-67
pubmed: 11438483
Br J Haematol. 2003 Aug;122(3):454-6
pubmed: 12877673
Biochem J. 2004 Aug 15;382(Pt 1):1-11
pubmed: 15193142
Cancer Cell. 2004 Aug;6(2):117-27
pubmed: 15324695
World J Gastroenterol. 2004 Nov 1;10(21):3225-9
pubmed: 15457582
Gene. 2006 Jun 7;374:1-9
pubmed: 16675164
Nat Med. 2007 Jan;13(1):84-8
pubmed: 17159987
Cell. 2007 Jan 12;128(1):141-56
pubmed: 17218261
Cell. 2007 Jan 12;128(1):157-70
pubmed: 17218262
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7564-9
pubmed: 17452630
Br J Cancer. 2007 Oct 22;97(8):1139-45
pubmed: 17940504
J Cell Sci. 2007 Dec 1;120(Pt 23):4071-9
pubmed: 18032782
Neuroscience. 2008 Jan 24;151(2):476-88
pubmed: 18082964
J Mol Diagn. 2008 Jan;10(1):13-27
pubmed: 18165277
BMC Cancer. 2008 Feb 06;8:43
pubmed: 18254976
Mol Cell Biol. 2008 May;28(10):3281-9
pubmed: 18332125
Eur J Cancer. 2008 May;44(7):946-53
pubmed: 18396036
Cell. 2008 May 2;133(3):403-14
pubmed: 18455982
J Neurosci. 2008 Jun 4;28(23):5870-8
pubmed: 18524891
BMC Gastroenterol. 2008 Nov 26;8:56
pubmed: 19036165
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):480-5
pubmed: 19114656
Br J Cancer. 2008 Sep 16;99(6):923-9
pubmed: 19238633
Cancer Cell. 2009 Apr 7;15(4):304-14
pubmed: 19345329
J Clin Oncol. 2009 Jun 1;27(16):2622-9
pubmed: 19398573
J Natl Cancer Inst. 2009 Oct 7;101(19):1308-24
pubmed: 19738166
J Invest Dermatol. 2010 Feb;130(2):620-2
pubmed: 19798057
Nature. 2009 Oct 22;461(7267):1084-91
pubmed: 19847259
Histopathology. 2010 Jan;56(2):229-39
pubmed: 20102402
Oncology. 2010;78(2):141-9
pubmed: 20389136
Anticancer Res. 2010 Mar;30(3):981-5
pubmed: 20393024
Nat Genet. 2010 May;42(5):454-8
pubmed: 20400965
J Clin Invest. 2010 Jun;120(6):2094-108
pubmed: 20458142
Int J Hematol. 2010 Jul;92(1):83-94
pubmed: 20582577
Clin Cancer Res. 2010 Sep 1;16(17):4325-30
pubmed: 20622047
J Clin Invest. 2010 Aug;120(8):2858-66
pubmed: 20664172
Cancer Res. 2010 Sep 15;70(18):7114-24
pubmed: 20807812
Cancer. 2011 Jan 15;117(2):290-300
pubmed: 20830770
Sci Signal. 2010 Nov 02;3(146):pe39
pubmed: 21045203
J Clin Oncol. 2011 Jan 10;29(2):166-73
pubmed: 21135276
Nat Rev Clin Oncol. 2011 Mar;8(3):135-41
pubmed: 21364686
Genome Biol. 2011;12(4):R41
pubmed: 21527027
Nat Commun. 2011;2:307
pubmed: 21556061
Ther Adv Med Oncol. 2010 Mar;2(2):125-48
pubmed: 21789130
Arch Med Res. 2011 Oct;42(7):584-8
pubmed: 22036936
J Mol Med (Berl). 2012 Jun;90(6):667-79
pubmed: 22215152
Biochem J. 2012 Jun 15;444(3):457-64
pubmed: 22413754
Oncogene. 2013 Jan 24;32(4):403-13
pubmed: 22430211
Nat Rev Mol Cell Biol. 2012 Apr 04;13(5):283-96
pubmed: 22473468
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
Curr Opin Neurobiol. 2012 Oct;22(5):873-9
pubmed: 22664040
Mod Pathol. 2012 Nov;25(11):1543-9
pubmed: 22684219
Nat Commun. 2012 Jun 19;3:911
pubmed: 22713753
N Biotechnol. 2012 Sep 15;29(6):689-94
pubmed: 22743138
Cell. 2012 Jul 20;150(2):251-63
pubmed: 22817889
Eur Urol. 2013 Aug;64(2):177-88
pubmed: 22939387
Hum Pathol. 2013 Jun;44(6):1024-30
pubmed: 23260327
Int J Cancer. 2013 Jul 15;133(2):323-34
pubmed: 23319441
Nat Struct Mol Biol. 2013 Apr;20(4):440-6
pubmed: 23435381
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Br J Cancer. 2013 May 28;108(10):2153-63
pubmed: 23660947
PLoS One. 2013 Jun 13;8(6):e65821
pubmed: 23785454
Elife. 2013 Jul 09;2:e00691
pubmed: 23853711
Oncol Lett. 2013 Jul;6(1):161-168
pubmed: 23946797
Eur J Cancer. 2014 Jan;50(1):216-25
pubmed: 24054978
Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):594-600
pubmed: 24515272
J Urol. 2014 Sep;192(3):940-6
pubmed: 24704020
Cancer Immunol Res. 2014 Apr;2(4):361-70
pubmed: 24764583
Cell. 2014 Apr 24;157(3):595-610
pubmed: 24766807
Int J Urol. 2014 Dec;21(12):1209-14
pubmed: 25099119
Clin Cancer Res. 2014 Nov 1;20(21):5527-36
pubmed: 25165098
Cell Rep. 2014 Oct 9;9(1):75-89
pubmed: 25263564
Drug Des Devel Ther. 2014 Oct 06;8:1745-51
pubmed: 25336918
Ann Oncol. 2015 Jan;26(1):120-5
pubmed: 25361980
Methods. 2015 May;77-78:147-56
pubmed: 25448478
Front Oncol. 2015 Feb 16;5:24
pubmed: 25763354
Anal Cell Pathol (Amst). 2015;2015:746856
pubmed: 26114084
Int J Clin Exp Med. 2015 Apr 15;8(4):5430-7
pubmed: 26131120
Front Oncol. 2015 Jul 27;5:166
pubmed: 26284192
Br J Cancer. 2015 Oct 20;113(8):1225-33
pubmed: 26379078
Nat Rev Drug Discov. 2015 Dec;14(12):812-3
pubmed: 26471367
J Clin Oncol. 2016 Feb 10;34(5):419-26
pubmed: 26503204
Cancer Discov. 2016 Feb;6(2):202-16
pubmed: 26645196
Hematol Rep. 2015 Dec 09;7(4):5844
pubmed: 26734127
J Biomed Sci. 2016 Jan 19;23:9
pubmed: 26787105
Cancer Discov. 2016 Feb;6(2):128-9
pubmed: 26851183
Asian Pac J Cancer Prev. 2016;17(S3):305-9
pubmed: 27165243
J Biol Chem. 2016 Jul 1;291(27):14160-9
pubmed: 27226612
Onco Targets Ther. 2016 Jun 13;9:3485-92
pubmed: 27366085
Semin Cell Dev Biol. 2017 Apr;64:65-72
pubmed: 27569190
Trends Pharmacol Sci. 2017 Jan;38(1):41-54
pubmed: 27789023
JAMA Oncol. 2017 Apr 1;3(4):516-522
pubmed: 27978579
Sci Rep. 2017 Feb 21;7:43013
pubmed: 28220839
Immunity. 2017 Feb 21;46(2):197-204
pubmed: 28228279
Oncogene. 2017 Jun 29;36(26):3673-3685
pubmed: 28263967
Cell Mol Life Sci. 2017 Aug;74(15):2783-2794
pubmed: 28289760
Nat Commun. 2017 Mar 23;8:14771
pubmed: 28332494
Onco Targets Ther. 2017 Apr 12;10:2115-2126
pubmed: 28442920
Endocrinol Metab Clin North Am. 2017 Jun;46(2):503-517
pubmed: 28476234
Leukemia. 2017 Dec;31(12):2594-2600
pubmed: 28539671
Ann Oncol. 2017 Nov 1;28(11):2896-2898
pubmed: 28666315
PLoS One. 2017 Jul 3;12(7):e0179437
pubmed: 28672019
Breast. 2017 Aug;34 Suppl 1:S19-S26
pubmed: 28687441
Eur Rev Med Pharmacol Sci. 2017 Jul;21(3 Suppl):20-26
pubmed: 28745797
J Exp Clin Cancer Res. 2017 Dec 28;36(1):192
pubmed: 29282151
J Breast Cancer. 2017 Dec;20(4):321-326
pubmed: 29285035
Mol Cytogenet. 2018 Jan 3;11:1
pubmed: 29308088
Clin Chim Acta. 2018 May;480:92-98
pubmed: 29408173
Nat Rev Urol. 2018 Apr;15(4):222-234
pubmed: 29460925
Cell. 2018 Apr 19;173(3):595-610.e11
pubmed: 29656894
Nat Rev Mol Cell Biol. 2018 Sep;19(9):547-562
pubmed: 29858604
Nat Commun. 2018 Jun 19;9(1):2392
pubmed: 29921876
Br J Haematol. 2018 Sep;182(5):705-711
pubmed: 29938780
Int J Mol Sci. 2018 Aug 19;19(8):null
pubmed: 30126252
J Invest Dermatol. 2019 Feb;139(2):430-438
pubmed: 30148988
Nat Rev Cancer. 2018 Nov;18(11):696-705
pubmed: 30293088
Acta Obstet Gynecol Scand. 2019 Mar;98(3):275-286
pubmed: 30511743
J Clin Invest. 2019 Feb 1;129(2):452-464
pubmed: 30614812
Nat Genet. 1997 Apr;15(4):356-62
pubmed: 9090379
Cancer Res. 1998 Feb 1;58(3):509-11
pubmed: 9458098
J Biol Chem. 1998 May 29;273(22):13375-8
pubmed: 9593664
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13513-8
pubmed: 9811831