Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases.

Amino Acid Substitution Animals Heme Mice Models, Chemical Mutation, Missense Nitric Oxide / chemistry Nitric Oxide Synthase Type I / chemistry Nitric Oxide Synthase Type II / chemistry Oxidation-Reduction Rats
computational biology dioxygenation enzyme kinetics enzyme mechanism heme heme protein heme-thiolate nitric oxide nitric-oxide synthase reaction mechanism redox reaction thermodynamics

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
10 05 2019
Historique:
received: 30 01 2019
revised: 27 03 2019
pubmed: 31 3 2019
medline: 18 12 2019
entrez: 31 3 2019
Statut: ppublish

Résumé

Nitric oxide (NO) synthases (NOSs) catalyze the formation of NO from l-arginine. We have shown previously that the NOS enzyme catalytic cycle involves a large number of reactions but can be characterized by a global model with three main rate-limiting steps. These are the rate of heme reduction by the flavin domain (

Identifiants

DOI: 10.1074/jbc.RA119.007810 PMID: 30926606 PMC: PMC6514623
pubmed: 30926606
pii: S0021-9258(20)35480-6
doi: 10.1074/jbc.RA119.007810
pmc: PMC6514623
doi:

Substances chimiques

Nitric Oxide 31C4KY9ESH
Heme 42VZT0U6YR
Nitric Oxide Synthase Type I EC 1.14.13.39
Nitric Oxide Synthase Type II EC 1.14.13.39
Nos1 protein, rat EC 1.14.13.39
Nos2 protein, mouse EC 1.14.13.39

Banques de données

PDB
['2G6K', '1NOD', '1NPF']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

7904-7916

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM051491
Pays : United States

Informations de copyright

© 2019 Tejero et al.

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Auteurs

Jesús Tejero (J)

From the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 and.
ORCID: 0000-0003-3245-9978

Andrew P Hunt (AP)

the Department of Chemistry and Department of Biophysics, University of Michigan, Ann Arbor, Michigan 48109.
ORCID: 0000-0003-0565-9050

Jérôme Santolini (J)

From the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 and.
ORCID: 0000-0001-8919-112X

Nicolai Lehnert (N)

the Department of Chemistry and Department of Biophysics, University of Michigan, Ann Arbor, Michigan 48109.
ORCID: 0000-0002-5221-5498

Dennis J Stuehr (DJ)

From the Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195 and stuehrd@ccf.org.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Substitution d'acide aminé › Mechanism and regulation of ferrous...
questionsmedicales.fr › Eucaryotes › Animaux › Mechanism and regulation of ferrous...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Mechanism and regulation of ferrous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mechanism and regulation of ferrous...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles chimiques › Mechanism and regulation of ferrous...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › Mechanism and regulation of ferrous...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Mechanism and regulation of ferrous...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Amino-acid oxidoreductases › Nitric oxide synthase › Nitric oxide synthase type I › Mechanism and regulation of ferrous...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Nitric oxide synthase type II › Mechanism and regulation of ferrous...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Mechanism and regulation of ferrous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Mechanism and regulation of ferrous...