Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
08
01
2018
accepted:
07
02
2019
entrez:
31
3
2019
pubmed:
31
3
2019
medline:
20
4
2019
Statut:
ppublish
Résumé
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Identifiants
pubmed: 30926973
doi: 10.1038/s41588-019-0378-y
pii: 10.1038/s41588-019-0378-y
pmc: PMC6467258
mid: NIHMS1521094
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
636-648Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK093757
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007048
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG009740
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 HG200362
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12015/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL142302
Pays : United States
Organisme : Medical Research Council
ID : MR/L01341X/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U01 AG023746
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182913
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HG200362-02
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F019394/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : K01 HL135405
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL046380
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113338
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117445
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK072193
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Organisme : NIDDK NIH HHS
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Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA173640
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Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : NIDDK NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : NHLBI NIH HHS
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Pays : United States
Organisme : Medical Research Council
ID : MR/R023484/1
Pays : United Kingdom
Organisme : Intramural NIH HHS
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Organisme : Medical Research Council
ID : MR/L01632X/1
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Organisme : Medical Research Council
ID : MR/K002414/1
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Organisme : NHLBI NIH HHS
ID : U01 HL137162
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ID : MC_UU_00007/10
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Organisme : NIDDK NIH HHS
ID : U01 DK062370
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Organisme : Medical Research Council
ID : MC_UP_1605/7
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Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182910
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD050924
Pays : United States
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