Adjuvant Treatment of Hepatocellular Carcinoma: Prospect of Immunotherapy.


Journal

Hepatology (Baltimore, Md.)
ISSN: 1527-3350
Titre abrégé: Hepatology
Pays: United States
ID NLM: 8302946

Informations de publication

Date de publication:
10 2019
Historique:
received: 30 10 2018
accepted: 19 03 2019
pubmed: 31 3 2019
medline: 26 6 2020
entrez: 31 3 2019
Statut: ppublish

Résumé

Although patients undergo procedures with curative intent for early-stage hepatocellular carcinoma (HCC), up to 70% of patients may have disease recurrence in the liver at 5 years. Thus far, no therapy has proven to be effective in the adjuvant setting. Here, we discuss the application of immune-based therapies in the adjuvant setting for HCC, focusing on the underlying rationale for immunotherapies, which patients may benefit from an immune-based therapy, and what type of immune therapy should be implemented.

Identifiants

pubmed: 30927283
doi: 10.1002/hep.30633
doi:

Types de publication

Journal Article Research Support, N.I.H., Intramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1437-1442

Subventions

Organisme : Intramural Research Program of the NIH, NCI
Pays : International

Informations de copyright

Published 2019. This article is a U.S. Government work and is in the public domain in the USA.

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Auteurs

Zachary J Brown (ZJ)

Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Tim F Greten (TF)

Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
National Cancer Institute, Center for Cancer Research Liver Cancer Program, National Institutes of Health, Bethesda, MD.

Bernd Heinrich (B)

Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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