Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review.
Epithelial-mesenchymal transition
Head and neck cancer
Tumor metabolism
Tumor microenvironment
Journal
Molecular cancer
ISSN: 1476-4598
Titre abrégé: Mol Cancer
Pays: England
ID NLM: 101147698
Informations de publication
Date de publication:
30 03 2019
30 03 2019
Historique:
received:
17
12
2018
accepted:
25
02
2019
entrez:
1
4
2019
pubmed:
1
4
2019
medline:
3
8
2019
Statut:
epublish
Résumé
The tumor microenvironment (TME) is comprised of many different cell populations, such as cancer-associated fibroblasts and various infiltrating immune cells, and non-cell components of extracellular matrix. These crucial parts of the surrounding stroma can function as both positive and negative regulators of all hallmarks of cancer development, including evasion of apoptosis, induction of angiogenesis, deregulation of the energy metabolism, resistance to the immune detection and destruction, and activation of invasion and metastasis. This review represents a summary of recent studies focusing on describing these effects of microenvironment on initiation and progression of the head and neck squamous cell carcinoma, focusing on oral squamous cell carcinoma, since it is becoming clear that an investigation of differences in stromal composition of the head and neck squamous cell carcinoma microenvironment and their impact on cancer development and progression may help better understand the mechanisms behind different responses to therapy and help define possible targets for clinical intervention.
Identifiants
pubmed: 30927923
doi: 10.1186/s12943-019-0983-5
pii: 10.1186/s12943-019-0983-5
pmc: PMC6441173
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Pagination
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