In Vitro Granuloma Models of Tuberculosis: Potential and Challenges.
granuloma
tissue culture models
tuberculosis
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
24 05 2019
24 05 2019
Historique:
received:
09
10
2018
accepted:
08
01
2019
pubmed:
1
4
2019
medline:
25
2
2020
entrez:
1
4
2019
Statut:
ppublish
Résumé
Despite intensive research efforts, several fundamental disease processes for tuberculosis (TB) remain poorly understood. A central enigma is that host immunity is necessary to control disease yet promotes transmission by causing lung immunopathology. Our inability to distinguish these processes makes it challenging to design rational novel interventions. Elucidating basic immune mechanisms likely requires both in vivo and in vitro analyses, since Mycobacterium tuberculosis is a highly specialized human pathogen. The classic immune response is the TB granuloma organized in three dimensions within extracellular matrix. Several groups are developing cell culture granuloma models. In January 2018, NIAID convened a workshop, entitled "3-D Human in vitro TB Granuloma Model" to advance the field. Here, we summarize the arguments for developing advanced TB cell culture models and critically review those currently available. We discuss how integrating complementary approaches, specifically organoids and mathematical modeling, can maximize progress, and conclude by discussing future challenges and opportunities.
Identifiants
pubmed: 30929010
pii: 5423999
doi: 10.1093/infdis/jiz020
pmc: PMC6534193
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1858-1866Subventions
Organisme : Medical Research Council
ID : MR/P023754/1
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR001070
Pays : United States
Organisme : NIAID NIH HHS
ID : R33 AI102239
Pays : United States
Organisme : NHLBI NIH HHS
ID : DP2 HL127720
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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