A Role of Drd2 Hippocampal Neurons in Context-Dependent Food Intake.
dopamine receptor 2
feeding
food intake
hippocampus
memory
optogenetics
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
22 05 2019
22 05 2019
Historique:
received:
10
06
2018
revised:
16
11
2018
accepted:
05
03
2019
pubmed:
2
4
2019
medline:
26
3
2020
entrez:
2
4
2019
Statut:
ppublish
Résumé
Associative learning of food cues that link location in space to food availability guides feeding behavior in mammals. However, the function of specific neurons that are elements of the higher-order, cognitive circuitry controlling feeding behavior is largely unexplored. Here, we report that hippocampal dopamine 2 receptor (hD2R) neurons are specifically activated by food and that both acute and chronic modulation of their activity reduces food intake in mice. Upstream projections from the lateral entorhinal cortex (LEC) to the hippocampus activate hD2R cells and can also decrease food intake. Finally, activation of hD2R neurons interferes with the encoding of a spatial memory linking food to a specific location via projections from the hippocampus to the septal area. Altogether these data describe a previously unidentified LEC > hippocampus > septal higher-order circuit that regulates feeding behavior.
Identifiants
pubmed: 30930044
pii: S0896-6273(19)30218-1
doi: 10.1016/j.neuron.2019.03.011
pii:
doi:
Substances chimiques
DRD2 protein, mouse
0
Receptors, Dopamine D2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
873-886.e5Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.