IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice.
NLRP3 inflammasome
atrial fibrillation
hypertension
Journal
Biological & pharmaceutical bulletin
ISSN: 1347-5215
Titre abrégé: Biol Pharm Bull
Pays: Japan
ID NLM: 9311984
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
2
4
2019
pubmed:
2
4
2019
medline:
2
8
2019
Statut:
ppublish
Résumé
Hypertension is one risk for atrial fibrillation (AF) and induces cardiac inflammation. Recent evidence indicates that pressure overload-induced ventricular structural remodeling is associated with the activation of nucleotide binding-oligomerization domain (NOD)-like receptor P3 (NLRP3) inflammasomes, including an apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC). We hypothesized that NLRP3 inflammasomes are an initial sensor for danger signals in pressure overload-induced atrial remodeling, leading to AF. Transverse aortic constriction (TAC) or a sham procedure was performed in mice deficient for ASC
Identifiants
pubmed: 30930414
doi: 10.1248/bpb.b18-00363
doi:
Substances chimiques
CARD Signaling Adaptor Proteins
0
Ccl2 protein, mouse
0
Chemokine CCL2
0
Interleukin-1beta
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Nlrp3 protein, mouse
0
Pycard protein, mouse
0
Types de publication
Journal Article
Langues
eng