Effects of in-Scanner Bilateral Frontal tDCS on Functional Connectivity of the Working Memory Network in Older Adults.
DLPFC (dorsolateral prefrontal cortex)
cognitive aging
fMRI—functional magnetic resonance imaging
functional connectivity
tDCS
transcranial direct cortical stimulation (tDCS)
working memory
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
12
2018
accepted:
22
02
2019
entrez:
2
4
2019
pubmed:
2
4
2019
medline:
2
4
2019
Statut:
epublish
Résumé
Working memory is an executive memory process essential for everyday decision-making and problem solving that declines with advanced age. Transcranial direct current stimulation (tDCS) is a non-invasive form of brain stimulation that has demonstrated potential for improving working memory performance in older adults. However, the neural mechanisms underlying effects of tDCS on working memory are not well understood. This mechanistic study investigated the acute and after-effects of bilateral frontal (F3/F4) tDCS at 2 mA for 12-min on functional connectivity of the working memory network in older adults. We hypothesized active tDCS over sham would increase frontal connectivity during working memory performance. The study used a double-blind within-subject 2 session crossover design. Participants performed an functional magnetic resonance imaging (fMRI) N-Back working memory task before, during, and after active or sham stimulation. Functional connectivity of the working memory network was assessed within and between stimulation conditions (FDR < 0.05). Active tDCS produced a significant increase in functional connectivity between left ventrolateral prefrontal cortex (VLPFC) and left dorsolateral PFC (DLPFC) during stimulation, but not after stimulation. Connectivity did not significantly increase with sham stimulation. In addition, our data demonstrated both state-dependent and time-dependent effects of tDCS working memory network connectivity in older adults. tDCS during working memory performance produces a selective change in functional connectivity of the working memory network in older adults. These data provide important mechanistic insight into the effects of tDCS on brain connectivity in older adults, as well as key methodological considerations for tDCS-working memory studies.
Identifiants
pubmed: 30930766
doi: 10.3389/fnagi.2019.00051
pmc: PMC6428720
doi:
Types de publication
Journal Article
Langues
eng
Pagination
51Subventions
Organisme : NIA NIH HHS
ID : K01 AG050707
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001429
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054077
Pays : United States
Organisme : NIH HHS
ID : S10 OD021726
Pays : United States
Références
Brain Cogn. 1999 Oct;41(1):66-86
pubmed: 10536086
J Physiol. 2000 Sep 15;527 Pt 3:633-9
pubmed: 10990547
J Neurosci. 2000 Oct 1;20(19):7496-503
pubmed: 11007909
Trends Cogn Sci. 2001 Nov 1;5(11):479-486
pubmed: 11684480
Neuroimage. 2002 Nov;17(3):1394-402
pubmed: 12414279
Clin Neurophysiol. 2003 Apr;114(4):600-4
pubmed: 12686268
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
J Physiol. 2003 Nov 15;553(Pt 1):293-301
pubmed: 12949224
J Physiol. 1964 Aug;172:369-82
pubmed: 14199369
Nat Rev Neurosci. 2003 Oct;4(10):829-39
pubmed: 14523382
Neuroimage. 2004 Jan;21(1):450-5
pubmed: 14741682
Eur J Neurosci. 2004 May;19(10):2720-6
pubmed: 15147306
Hum Brain Mapp. 2005 May;25(1):46-59
pubmed: 15846822
Brain. 2006 Dec;129(Pt 12):3315-28
pubmed: 16984899
J Neurosci. 2006 Dec 20;26(51):13338-43
pubmed: 17182784
Science. 1992 Jan 31;255(5044):556-9
pubmed: 1736359
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Neuropsychology. 2007 Sep;21(5):532-9
pubmed: 17784801
Neuron. 2007 Dec 6;56(5):924-35
pubmed: 18054866
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1279-84
pubmed: 19164577
Magn Reson Imaging. 2010 Oct;28(8):1051-7
pubmed: 20409665
Psychol Aging. 2011 Dec;26(4):813-22
pubmed: 21707176
Nature. 2011 Jul 27;476(7359):210-3
pubmed: 21796118
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Brain Stimul. 2013 May;6(3):424-32
pubmed: 22695026
Cortex. 2013 May;49(5):1195-205
pubmed: 22789779
Cereb Cortex. 2013 Oct;23(10):2457-66
pubmed: 22879354
J Physiol. 2013 Apr 1;591(7):1987-2000
pubmed: 23339180
Int J Neuropsychopharmacol. 2013 Oct;16(9):1927-36
pubmed: 23719048
J Cogn Neurosci. 2014 Nov;26(11):2443-54
pubmed: 24742190
Ann Indian Acad Neurol. 2014 Jan;17(1):71-6
pubmed: 24753664
Exp Brain Res. 2014 Oct;232(10):3345-51
pubmed: 24992897
J Exp Psychol Learn Mem Cogn. 1989 May;15(3):507-16
pubmed: 2524548
Brain Stimul. 2015 Mar-Apr;8(2):253-9
pubmed: 25465291
Int J Neuropsychopharmacol. 2014 Oct 31;18(2):null
pubmed: 25522391
Cortex. 2015 Mar;64:271-80
pubmed: 25562175
PLoS One. 2015 Apr 07;10(4):e0121904
pubmed: 25849358
Clin Neurophysiol. 2016 Feb;127(2):1031-1048
pubmed: 26652115
Neural Plast. 2016;2016:8240894
pubmed: 26819776
Brain Stimul. 2016 Jul-Aug;9(4):553-9
pubmed: 27178247
Brain Stimul. 2016 Sep-Oct;9(5):641-661
pubmed: 27372845
PLoS One. 2016 Jul 21;11(7):e0159198
pubmed: 27442504
Front Aging Neurosci. 2017 Jan 04;8:328
pubmed: 28101053
Front Hum Neurosci. 2017 Jul 12;11:366
pubmed: 28747880
Brain Stimul. 2018 Jan - Feb;11(1):52-58
pubmed: 29066167
Brain Stimul. 2018 May - Jun;11(3):465-480
pubmed: 29398575
Front Aging Neurosci. 2018 Jun 08;10:177
pubmed: 29950986
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13473-80
pubmed: 8942959