Allosteric inhibition of α-thrombin enzymatic activity with ultrasmall gold nanoparticles.
Journal
Nanoscale advances
ISSN: 2516-0230
Titre abrégé: Nanoscale Adv
Pays: England
ID NLM: 101738708
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
11
07
2018
accepted:
21
09
2018
entrez:
2
4
2019
pubmed:
2
4
2019
medline:
2
4
2019
Statut:
ppublish
Résumé
The catalytic activity of enzymes can be regulated by interactions with synthetic nanoparticles (NPs) in a number of ways. To date, however, the potential use of NPs as allosteric effectors has not been investigated in detail. Importantly, targeting allosteric (distal) sites on the enzyme surface could afford unique ways to modulate the activity, allowing for either enzyme activation, partial or full inhibition. Using
Identifiants
pubmed: 30931428
doi: 10.1039/c8na00081f
pii: c8na00081f
pmc: PMC6394888
doi:
Types de publication
Journal Article
Langues
eng
Pagination
378-388Références
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