Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
pubmed:
2
4
2019
medline:
19
4
2019
entrez:
2
4
2019
Statut:
ppublish
Résumé
A series of cyclic lipidated oligo-Arg cell penetrating peptides were synthesised with varied macrocycle size and lipid chain anchoring site. The study of their cellular uptake revealed different structural requirements to promote efficient glycosaminoglycan-dependent endocytosis and direct translocation.
Substances chimiques
Cell-Penetrating Peptides
0
Glycosaminoglycans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4566-4569Subventions
Organisme : Medical Research Council
ID : MC_U117592730
Pays : United Kingdom