Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment.


Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
13 09 2019
Historique:
received: 24 10 2018
accepted: 21 01 2019
pubmed: 2 4 2019
medline: 10 9 2020
entrez: 2 4 2019
Statut: ppublish

Résumé

Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.

Identifiants

pubmed: 30933266
pii: 5305974
doi: 10.1093/cid/ciz074
doi:

Substances chimiques

Antitubercular Agents 0
Diarylquinolines 0
Nitroimidazoles 0
OPC-67683 0
Oxazoles 0
bedaquiline 78846I289Y

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1229-1231

Commentaires et corrections

Type : CommentIn

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Auteurs

Silke Polsfuss (S)

Institute for Microbiology, Immunology and Laboratory Medicine, Helios Klinikum Emil von Behring, Berlin.

Sabine Hofmann-Thiel (S)

Synlab Gauting, synlab MVZ Humane Genetik.
IML red GmbH, Tuberculosis Supranational Reference Laboratory, Gauting.

Matthias Merker (M)

Molecular and Experimental Mycobacteriology, Research Center Borstel.
German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel.

David Krieger (D)

Department of Pneumology, Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin.

Stefan Niemann (S)

Molecular and Experimental Mycobacteriology, Research Center Borstel.
German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel.

Holger Rüssmann (H)

Institute for Microbiology, Immunology and Laboratory Medicine, Helios Klinikum Emil von Behring, Berlin.

Nicolas Schönfeld (N)

Department of Pneumology, Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin.

Harald Hoffmann (H)

Synlab Gauting, synlab MVZ Humane Genetik.
IML red GmbH, Tuberculosis Supranational Reference Laboratory, Gauting.

Katharina Kranzer (K)

National Reference Laboratory for Mycobacteria, Research Center Borstel, Borstel, Germany.
Clinical Research Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom.

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Classifications MeSH