Tailored management of primary gastrointestinal stromal tumors.
adjuvant
gastrointestinal stromal tumor
imatinib
primary
surgery
Journal
Cancer
ISSN: 1097-0142
Titre abrégé: Cancer
Pays: United States
ID NLM: 0374236
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
29
11
2018
revised:
10
02
2019
accepted:
14
02
2019
pubmed:
2
4
2019
medline:
25
3
2020
entrez:
2
4
2019
Statut:
ppublish
Résumé
Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and can form along the entire gastrointestinal tract. Over the last 20 years, considerable advances have been made in our understanding of the biology of GISTs. The advent of tyrosine kinase inhibitors has provided effective medical therapy for the first time. In fact, given that GIST typically is driven by either a KIT or PDGFRA gene mutation, it has become a paradigm of targeted molecular therapy. In addition, diagnostic and surgical techniques have been refined. Here, the critical aspects of primary GISTs and how they are now managed with an integrated approach are summarized. Treatment plans are developed based on specific pathologic and molecular features of the tumor. The authors outline the general principles of therapy and highlight some of the nuances. Particular focus is given to diagnosis, surgical considerations, and the use of preoperative and postoperative tyrosine kinase inhibitors.
Identifiants
pubmed: 30933313
doi: 10.1002/cncr.32067
pmc: PMC6773539
mid: NIHMS1015674
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2164-2171Subventions
Organisme : NCI NIH HHS
ID : R01 CA102613
Pays : United States
Informations de copyright
© 2019 American Cancer Society.
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