Quantitative CT and pulmonary function in children with post-infectious bronchiolitis obliterans.
Adolescent
Bronchiolitis Obliterans
/ diagnosis
Child
Child, Preschool
Feasibility Studies
Female
Humans
Lung
/ diagnostic imaging
Male
Predictive Value of Tests
Radiography, Thoracic
/ methods
Respiratory Function Tests
/ methods
Respiratory Tract Infections
/ complications
Retrospective Studies
Tomography, X-Ray Computed
/ methods
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
10
2018
accepted:
05
03
2019
entrez:
2
4
2019
pubmed:
2
4
2019
medline:
14
1
2020
Statut:
epublish
Résumé
To investigate the feasibility of CT-based quantitative airway and air-trapping measurements and to assess their correlation with pulmonary function in children with post-infectious bronchiolitis obliterans (PIBO). This retrospective study approved by the institutional review board included chest CT scans and pulmonary function tests (PFT) completed between January 2005 and December 2016 in children diagnosed with PIBO. The quantitative analysis of segmental and subsegmental bronchi was performed on each chest CT scan, measuring the areas or diameters of lumens, walls, or the entire airway. The air-trapping volume (ATV), the volume of lung area exhibiting lower attenuation than the mean attenuation of normal and air-trapping areas, was also measured in each lobe. Comparison analyses between CT parameters and PFT results were performed with Pearson or Spearman correlation. In total, 23 patients were enrolled (mean age 7.0 ± 3.3 years; range, 4-15 years). We successfully measured 89.6% of all segmental bronchi. In the airway analysis, wall area showed a negative correlation with forced expiratory volume in one second (FEV1) in the majority of the pulmonary lobes. Air-trapping analyses demonstrated that ATV was negatively correlated with FEV1 and positively correlated with reactance at 5 Hz. Quantitative airway and air-trapping measurements from chest CT are feasible and correlate with pulmonary function in pediatric PIBO patients.
Identifiants
pubmed: 30934017
doi: 10.1371/journal.pone.0214647
pii: PONE-D-18-30505
pmc: PMC6443232
doi:
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0214647Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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