Gray Matter Microstructural Abnormalities and Working Memory Deficits in Individuals with Schizophrenia.
Diffusion tensor imaging
Diffusivity
Gray matter
Schizophrenia
Working memory
Journal
Psychiatry investigation
ISSN: 1738-3684
Titre abrégé: Psychiatry Investig
Pays: Korea (South)
ID NLM: 101242994
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
30
05
2018
accepted:
14
10
2018
entrez:
2
4
2019
pubmed:
2
4
2019
medline:
2
4
2019
Statut:
ppublish
Résumé
Working memory impairments serve as prognostic factors for patients with schizophrenia. Working memory deficits are mainly associated with gray matter (GM) thickness and volume. We investigated the association between GM diffusivity and working memory in controls and individuals with schizophrenia. T1 and diffusion tensor images of the brain, working memory task (letter number sequencing) scores, and the demographic data of 90 individuals with schizophrenia and 97 controls were collected from the SchizConnect database. T1 images were parcellated into the 68 GM Regions of Interest (ROI). Axial Diffusivity (AD), Fractional Anisotropy (FA), Radial Diffusivity (RD), and Trace (TR) were calculated for each of the ROIs. Compared to the controls, schizophrenia group showed significantly increased AD, RD, and TR in specific regions on the frontal, temporal, and anterior cingulate area. Moreover, working memory was negatively correlated with AD, RD, and TR in the lateral orbitofrontal, superior temporal, inferior temporal, and rostral anterior cingulate area on left hemisphere in the individuals with schizophrenia. These results demonstrated GM microstructural abnormalities in the frontal, temporal, and anterior cingulate regions of individuals with schizophrenia. Furthermore, these regional GM microstructural abnormalities suggest a neuropathological basis for the working memory deficits observed clinically in individuals with schizophrenia.
Identifiants
pubmed: 30934191
pii: pi.2018.10.14.1
doi: 10.30773/pi.2018.10.14.1
pmc: PMC6444097
doi:
Types de publication
Journal Article
Langues
eng
Pagination
234-243Subventions
Organisme : NIMH NIH HHS
ID : 1U01MH097435
Pays : United States
Organisme : NIMH NIH HHS
ID : R01MH056584
Pays : United States
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