Apoptotic resistance in chronic lymphocytic leukemia and therapeutic perspectives.

Apoptosis Cell Survival / genetics Drug Resistance, Neoplasm / genetics Epigenesis, Genetic Humans Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy Models, Biological
BH3-mimetics CLL apoptosis

Journal

Critical reviews in clinical laboratory sciences
ISSN: 1549-781X
Titre abrégé: Crit Rev Clin Lab Sci
Pays: England
ID NLM: 8914816

Informations de publication

Date de publication:
08 2019
Historique:
pubmed: 3 4 2019
medline: 29 7 2020
entrez: 3 4 2019
Statut: ppublish

Résumé

Increased resistance to apoptosis represents a key oncogenic mechanism in chronic lymphocytic leukemia (CLL) that has been attributed to the upregulation of the anti-apoptotic B cell lymphoma 2 (Bcl-2) family members. Such an observation was associated with the development of molecules inhibiting Bcl-2 activity, and among them, BH3-mimetics represent a novel class of therapeutic compounds. In 2016, venetoclax became the first approved oral inhibitor of Bcl-2, and it has been used with success in patients with CLL who present with a 17p deletion or

Identifiants

DOI: 10.1080/10408363.2019.1600468 PMID: 30935269
pubmed: 30935269
doi: 10.1080/10408363.2019.1600468
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

321-332

Auteurs

Cristina Bagacean (C)

a Department of Hematology , Brest University Medical School Hospital , Brest , France.
b U1227 B Lymphocytes and Autoimmunity , University of Brest, INSERM, IBSAM , Brest , France.
c Laboratory of Immunology and Immunotherapy , Brest University Medical School Hospital , Brest , France.

Ciprian Tomuleasa (C)

d Research Center for Functional Genomics and Translational Medicine , "Iuliu Hatieganu" University of Medicine and Pharmacy , Cluj-Napoca , Romania.

Adrian Tempescul (A)

a Department of Hematology , Brest University Medical School Hospital , Brest , France.
b U1227 B Lymphocytes and Autoimmunity , University of Brest, INSERM, IBSAM , Brest , France.

Ravnit Grewal (R)

e South African National Bioinformatics Institute (SANBI) , University of the Western Cape , Cape Town , South Africa.

Wesley H Brooks (WH)

f Department of Chemistry , University of South Florida , Tampa , FL , USA.

Christian Berthou (C)

a Department of Hematology , Brest University Medical School Hospital , Brest , France.
b U1227 B Lymphocytes and Autoimmunity , University of Brest, INSERM, IBSAM , Brest , France.

Yves Renaudineau (Y)

c Laboratory of Immunology and Immunotherapy , Brest University Medical School Hospital , Brest , France.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Apoptotic resistance in chronic lymphocytic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Apoptotic resistance in chronic lymphocytic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Apoptotic resistance in chronic lymphocytic...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Apoptotic resistance in chronic lymphocytic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Apoptotic resistance in chronic lymphocytic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Leucémie chronique lymphocytaire à cellules B › Apoptotic resistance in chronic lymphocytic...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Apoptotic resistance in chronic lymphocytic...