Hypertriglyceridemia and hyperuricemia: a retrospective study of urban residents.
Hyperuricemia; triglyceride
Metabolism
Uric acid
Journal
Lipids in health and disease
ISSN: 1476-511X
Titre abrégé: Lipids Health Dis
Pays: England
ID NLM: 101147696
Informations de publication
Date de publication:
01 Apr 2019
01 Apr 2019
Historique:
received:
27
09
2018
accepted:
26
03
2019
entrez:
3
4
2019
pubmed:
3
4
2019
medline:
30
7
2019
Statut:
epublish
Résumé
The aim of this study was to determine the association between hypertriglyceridemia and hyperuricemia (HUA). The study was conducted in 3884 subjects who had not received medication enrolled as a baseline. Each participant received at least three annual health check-ups between 2011 and 2017. The risk of hyperuricemia was assessed in four Quartiles (Q1 to Q4) according to TG levels using multivariate-adjusted logistic regression models. The total incidence rate of HUA was 62.3/1000 person-years. In the univariate analysis, the risk of hyperuricemia in people with hypertriglyceridemia was 2.353 times that of normal triglycerides, with a 95% confidence interval of (2.011, 2.754), and the risk of hyperuricemia in men was 1.86 times of female, and the 95% confidence interval is (1.634, 2.177). After adjusting the potential confounders, the relative risk RR of TG at Q2 Q3 Q4 was 1.445 (95%CI:1.114, 1.901), 2.075 (1.611, 2.674), 2.972 (2.322, 3.804). TG is an independent risk factor for hyperuricemia. As the level of TG increases, the risk of HUA increases.
Sections du résumé
BACKGROUND
BACKGROUND
The aim of this study was to determine the association between hypertriglyceridemia and hyperuricemia (HUA).
METHODS
METHODS
The study was conducted in 3884 subjects who had not received medication enrolled as a baseline. Each participant received at least three annual health check-ups between 2011 and 2017. The risk of hyperuricemia was assessed in four Quartiles (Q1 to Q4) according to TG levels using multivariate-adjusted logistic regression models.
RESULTS
RESULTS
The total incidence rate of HUA was 62.3/1000 person-years. In the univariate analysis, the risk of hyperuricemia in people with hypertriglyceridemia was 2.353 times that of normal triglycerides, with a 95% confidence interval of (2.011, 2.754), and the risk of hyperuricemia in men was 1.86 times of female, and the 95% confidence interval is (1.634, 2.177). After adjusting the potential confounders, the relative risk RR of TG at Q2 Q3 Q4 was 1.445 (95%CI:1.114, 1.901), 2.075 (1.611, 2.674), 2.972 (2.322, 3.804).
CONCLUSIONS
CONCLUSIONS
TG is an independent risk factor for hyperuricemia. As the level of TG increases, the risk of HUA increases.
Identifiants
pubmed: 30935401
doi: 10.1186/s12944-019-1031-6
pii: 10.1186/s12944-019-1031-6
pmc: PMC6444567
doi:
Substances chimiques
Triglycerides
0
Uric Acid
268B43MJ25
Types de publication
Journal Article
Langues
eng
Pagination
81Subventions
Organisme : National Natural Science Foundation of China
ID : 81560343
Organisme : Science and Technology Plan Project of Gansu
ID : 18YF1FA108
Organisme : Lanzhou University Second Hospital Doctoral Research Fund Project
ID : Ynbskyjj2015-1-6
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