Amino acid transporters in the regulation of insulin secretion and signalling.
amino acid metabolism
amino acid transporters
fibroblast growth factor 21
insulin secretion
insulin signalling
type 2 diabetes
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
30 04 2019
30 04 2019
Historique:
received:
23
11
2018
revised:
24
02
2019
accepted:
25
02
2019
pubmed:
3
4
2019
medline:
9
11
2019
entrez:
3
4
2019
Statut:
ppublish
Résumé
Amino acids are increasingly recognised as modulators of nutrient disposal, including their role in regulating blood glucose through interactions with insulin signalling. More recently, cellular membrane transporters of amino acids have been shown to form a pivotal part of this regulation as they are primarily responsible for controlling cellular and circulating amino acid concentrations. The availability of amino acids regulated by transporters can amplify insulin secretion and modulate insulin signalling in various tissues. In addition, insulin itself can regulate the expression of numerous amino acid transporters. This review focuses on amino acid transporters linked to the regulation of insulin secretion and signalling with a focus on those of the small intestine, pancreatic β-islet cells and insulin-responsive tissues, liver and skeletal muscle. We summarise the role of the amino acid transporter B
Identifiants
pubmed: 30936244
pii: BST20180250
doi: 10.1042/BST20180250
doi:
Substances chimiques
Amino Acid Transport Systems
0
Insulin
0
fibroblast growth factor 21
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
571-590Informations de copyright
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.