Blood pressure response to exposure to moderate altitude in patients with COPD.
Adolescent
Adult
Aged
Altitude
Autonomic Nervous System
/ physiopathology
Baroreflex
Blood Pressure
Cardiovascular System
/ innervation
Circadian Rhythm
Female
Forced Expiratory Volume
Humans
Lung
/ physiopathology
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive
/ diagnosis
Severity of Illness Index
Time Factors
Young Adult
COPD
baroreflex sensitivity
blood pressure variability
hypobaric hypoxia
Journal
International journal of chronic obstructive pulmonary disease
ISSN: 1178-2005
Titre abrégé: Int J Chron Obstruct Pulmon Dis
Pays: New Zealand
ID NLM: 101273481
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
3
4
2019
pubmed:
3
4
2019
medline:
20
12
2019
Statut:
epublish
Résumé
Patients with COPD might be particularly susceptible to hypoxia-induced autonomic dysregulation. Decreased baroreflex sensitivity (BRS) and increased blood pressure (BP) variability (BPV) are markers of impaired cardiovascular autonomic regulation and there is evidence for an association between decreased BRS/increased BPV and high cardiovascular risk. The aim of this study was to evaluate the effect of short-term exposure to moderate altitude on BP and measures of cardiovascular autonomic regulation in COPD patients. Continuous morning beat-to-beat BP was noninvasively measured with a Finometer Thirty-seven patients with moderate to severe COPD (mean±SD age 64±6 years, FEV Exposure of COPD patients to moderate altitude is associated with a clinically relevant increase in BP, which seems to be related to autonomic dysregulation. ClinicalTrials.gov (NCT01875133).
Identifiants
pubmed: 30936690
doi: 10.2147/COPD.S194426
pii: copd-14-659
pmc: PMC6421900
doi:
Banques de données
ClinicalTrials.gov
['NCT01875133']
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
659-666Déclaration de conflit d'intérêts
Disclosure The authors declare no conflict of interest in this work.
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