Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues.
antivirals
herpes simplex virus
nucleic acids
nucleoside analogues
prodrugs
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
20 Mar 2019
20 Mar 2019
Historique:
received:
20
11
2018
revised:
04
01
2019
entrez:
3
4
2019
pubmed:
3
4
2019
medline:
3
4
2019
Statut:
epublish
Résumé
Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.
Identifiants
pubmed: 30937274
doi: 10.1002/advs.201802095
pii: ADVS991
pmc: PMC6425433
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1802095Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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