3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body.

Journal

ACS central science
ISSN: 2374-7943
Titre abrégé: ACS Cent Sci
Pays: United States
ID NLM: 101660035

Informations de publication

Date de publication:
27 Mar 2019
Historique:
received: 01 10 2018
entrez: 3 4 2019
pubmed: 3 4 2019
medline: 3 4 2019
Statut: ppublish

Résumé

Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. We have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the bloodstream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The support structure of the absorbers was built using 3D printing technology. This structure was coated with a nanostructured block copolymer with outer blocks that anchor the polymer chains to the 3D printed support structure and a middle block that has an affinity for the drug. The middle block is polystyrenesulfonate which binds to doxorubicin, a widely used and effective chemotherapy drug with significant toxic side effects. The absorbers are designed for deployment during chemotherapy using minimally invasive image-guided endovascular surgical procedures. We show that the introduction of the absorbers into the blood of swine models enables the capture of 64 ± 6% of the administered drug (doxorubicin) without any immediate adverse effects. Problems related to blood clots, vein wall dissection, and other biocompatibility issues were not observed. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.

Identifiants

DOI: 10.1021/acscentsci.8b00700 PMID: 30937369 PMC: PMC6439445
pubmed: 30937369
doi: 10.1021/acscentsci.8b00700
pmc: PMC6439445
doi:

Types de publication

Journal Article

Langues

eng

Pagination

419-427

Subventions

Organisme : NCI NIH HHS
ID : R01 CA194533
Pays : United States

Commentaires et corrections

Type : CommentIn

Déclaration de conflit d'intérêts

The authors declare the following competing financial interest(s): J.M.D. is the co-founder/CEO of and has an equity stake in Carbon, Inc., a 3D printing company commercializing continuous liquid interface production (CLIP) technology. G.R.R. is an employee, and F.M.B. is a former employee of Carbon, Inc. Carbon, Inc. is the manufacturer of CLIP equipment. CLIP is protected under issued US patents including 9,205,601, 9,211,678, and 9,216,546. S.W.H. and M.W.W. are the co-inventors of an in vivo positionable filtration device and methods related thereto to enable chemotherapy delivery in a targeted manner (WO/2014/100201).

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Auteurs

Hee Jeung Oh (HJ)

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.

Mariam S Aboian (MS)

Department of Radiology, School of Medicine, University of California, San Francisco, California 94110, United States.

Michael Y J Yi (MYJ)

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.

Jacqueline A Maslyn (JA)

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Energy Storage and Distributed Resources Division, Joint Center for Energy Storage Research (JCESR), Materials Sciences Division, Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Whitney S Loo (WS)

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.

Xi Jiang (X)

Energy Storage and Distributed Resources Division, Joint Center for Energy Storage Research (JCESR), Materials Sciences Division, Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Dilworth Y Parkinson (DY)

Energy Storage and Distributed Resources Division, Joint Center for Energy Storage Research (JCESR), Materials Sciences Division, Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Mark W Wilson (MW)

Department of Radiology, School of Medicine, University of California, San Francisco, California 94110, United States.

Terilyn Moore (T)

Department of Radiology, School of Medicine, University of California, San Francisco, California 94110, United States.

Colin R Yee (CR)

Department of Radiology, School of Medicine, University of California, San Francisco, California 94110, United States.

Gregory R Robbins (GR)

Carbon, Inc., 1089 Mills Way, Redwood City, California 94063, United States.

Florian M Barth (FM)

Carbon, Inc., 1089 Mills Way, Redwood City, California 94063, United States.

Joseph M DeSimone (JM)

Carbon, Inc., 1089 Mills Way, Redwood City, California 94063, United States.
Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States.

Steven W Hetts (SW)

Department of Radiology, School of Medicine, University of California, San Francisco, California 94110, United States.

Nitash P Balsara (NP)

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.
Energy Storage and Distributed Resources Division, Joint Center for Energy Storage Research (JCESR), Materials Sciences Division, Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Energy Storage and Distributed Resources Division, Joint Center for Energy Storage Research (JCESR), Materials Sciences Division, Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Energy Storage and Distributed Resources Division, Joint Center for Energy Storage Research (JCESR), Materials Sciences Division, Advanced Light Source Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Classifications MeSH