Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism.


Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
06 2019
Historique:
pubmed: 3 4 2019
medline: 27 5 2020
entrez: 3 4 2019
Statut: ppublish

Résumé

Current fructose consumption levels often overwhelm the intestinal capacity to absorb fructose. We investigated the impact of fructose malabsorption on intestinal endocrine function and addressed the role of the microbiota in this process. To answer this question, a mouse model of moderate fructose malabsorption [ketohexokinase mutant (KHK)

Identifiants

pubmed: 30939042
doi: 10.1096/fj.201801526RR
pmc: PMC6988857
doi:

Substances chimiques

Fructose 30237-26-4
Cholecystokinin 9011-97-6
Fructokinases EC 2.7.1.-
ketohexokinase EC 2.7.1.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7126-7142

Subventions

Organisme : NCCIH NIH HHS
ID : R01 AT010243
Pays : United States

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Auteurs

Xufei Zhang (X)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.
Collège Doctoral, Sorbonne Université, Paris, France.

Alexandra Grosfeld (A)

Centre de Recherche des Cordeliers, INSERM Unité Mixte de Recherche (UMR) S1138, Sorbonne Université, Sorbonne Cités, Université Paris-Diderot (UPD), Centre National de la Recherche Scientifique (CNRS)-Instituts Hospitalo-Universitaires (IHU), Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.

Edek Williams (E)

Department of Orthopedics, Rutgers University, Newark, New Jersey, USA.

Daniel Vasiliauskas (D)

Paris-Saclay Institute of Neuroscience, Université Paris Sud, Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, Gif-sur-Yvette, France.

Sharon Barretto (S)

Toxalim, Université de Toulouse, INRA, Toulouse, France.

Lorraine Smith (L)

Toxalim, Université de Toulouse, INRA, Toulouse, France.

Mahendra Mariadassou (M)

Mathématiques et Informatique Appliquées du Génome à l'Environnement (MaIAGE), Unité de Recherche (UR) 1404, INRA, Jouy-en-Josas, France.

Catherine Philippe (C)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Fabienne Devime (F)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Chloé Melchior (C)

INSERM Unit 1073, University of Rouen (UNIROUEN), Normandie University, Rouen, France.

Guillaume Gourcerol (G)

INSERM Unit 1073, University of Rouen (UNIROUEN), Normandie University, Rouen, France.

Nathalie Dourmap (N)

UNIROUEN, INSERM U1245 and Rouen University Hospital, Normandy Centre for Genomic and Personalized Medicine, Normandy University, Rouen, France.

Nicolas Lapaque (N)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Pierre Larraufie (P)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Hervé M Blottière (HM)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Christine Herberden (C)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Philippe Gerard (P)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

Jens F Rehfeld (JF)

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; and.

Ronaldo P Ferraris (RP)

Department of Pharmacology, Physiology, and Neuroscience, Rutgers University, Newark, New Jersey, USA.

J Christopher Fritton (JC)

Department of Orthopedics, Rutgers University, Newark, New Jersey, USA.

Sandrine Ellero-Simatos (S)

Toxalim, Université de Toulouse, INRA, Toulouse, France.

Veronique Douard (V)

Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

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Classifications MeSH