The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity.
DUSP10
MAPK
cancer
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Apr 2019
01 Apr 2019
Historique:
received:
13
02
2019
revised:
28
03
2019
accepted:
30
03
2019
entrez:
4
4
2019
pubmed:
4
4
2019
medline:
16
7
2019
Statut:
epublish
Résumé
Cancer is one of the most diagnosed diseases in developed countries. Inflammation is a common response to different stress situations including cancer and infection. In those processes, the family of mitogen-activated protein kinases (MAPKs) has an important role regulating cytokine secretion, proliferation, survival, and apoptosis, among others. MAPKs regulate a large number of extracellular signals upon a variety of physiological as well as pathological conditions. MAPKs activation is tightly regulated by phosphorylation/dephosphorylation events. In this regard, the dual-specificity phosphatase 10 (DUSP10) has been described as a MAPK phosphatase that negatively regulates p38 MAPK and c-Jun N-terminal kinase (JNK) in several cellular types and tissues. Several studies have proposed that extracellular signal-regulated kinase (ERK) can be also modulated by DUSP10. This suggests a complex role of DUSP10 on MAPKs regulation and, in consequence, its impact in a wide variety of responses involved in both cancer and inflammation. Here, we review DUSP10 function in cancerous and immune cells and studies in both mouse models and patients that establish a clear role of DUSP10 in different processes such as inflammation, immunity, and cancer.
Identifiants
pubmed: 30939861
pii: ijms20071626
doi: 10.3390/ijms20071626
pmc: PMC6480380
pii:
doi:
Substances chimiques
DUSP10 protein, human
EC 3.1.3.16
Mitogen-Activated Protein Kinase Phosphatases
EC 3.1.3.16
Dual-Specificity Phosphatases
EC 3.1.3.48
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : SAF-2013-42850-R
Organisme : Ministerio de Ciencia e Innovación
ID : SAF2016-75988-R
Organisme : Comunidad de Madrid
ID : S2017/BMD-3671
Organisme : Fondo de Investigaciones Sanitarias
ID : BIOMID
Organisme : Fundación Científica Asociación Española Contra el Cáncer
ID : AECC-AIO
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Biol Chem. 1999 Jul 9;274(28):19949-56
pubmed: 10391943
Oncogene. 1999 Nov 25;18(50):6981-8
pubmed: 10597297
Cytogenet Cell Genet. 2000;90(1-2):71-4
pubmed: 11060451
J Biol Chem. 2002 Aug 30;277(35):31818-25
pubmed: 12082107
Nature. 2004 Aug 12;430(7001):793-7
pubmed: 15306813
J Steroid Biochem Mol Biol. 2004 Oct;92(3):131-41
pubmed: 15555907
Cancer Res. 2006 Apr 15;66(8):4516-24
pubmed: 16618780
J Mol Biol. 2006 Jul 28;360(5):946-55
pubmed: 16806267
J Immunol. 2006 Dec 1;177(11):7497-504
pubmed: 17114416
Carcinogenesis. 2007 Jun;28(6):1188-96
pubmed: 17151092
Protein Sci. 2007 May;16(5):880-6
pubmed: 17400920
Cancer Metastasis Rev. 2008 Jun;27(2):253-61
pubmed: 18330678
J Biol Chem. 2008 May 23;283(21):14277-85
pubmed: 18356163
Exp Cell Res. 2008 Jun 10;314(10):2066-75
pubmed: 18410923
J Biol Chem. 2008 Sep 26;283(39):26591-601
pubmed: 18669639
Mol Cell Biol. 2009 Mar;29(6):1538-53
pubmed: 19139271
Nat Rev Cancer. 2009 Aug;9(8):537-49
pubmed: 19629069
EMBO J. 2009 Oct 7;28(19):2896-907
pubmed: 19696743
Am J Physiol Renal Physiol. 2009 Dec;297(6):F1622-31
pubmed: 19776174
Infect Immun. 2010 Jun;78(6):2454-65
pubmed: 20351145
Cell Oncol. 2010;32(5-6):361-72
pubmed: 20413845
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
J Biol Chem. 2011 Jun 3;286(22):19605-16
pubmed: 21487011
Cell Signal. 2012 May;24(5):1002-11
pubmed: 22245064
Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L866-74
pubmed: 22307906
Sci Signal. 2011 Dec 20;4(204):pe47
pubmed: 22375047
Sci Signal. 2011 Dec 20;4(204):ra88
pubmed: 22375048
J Biol Chem. 2012 May 18;287(21):17554-67
pubmed: 22467874
Cell Signal. 2012 Oct;24(10):1889-98
pubmed: 22683306
Oncol Rep. 2012 Sep;28(3):931-6
pubmed: 22711061
Cell Commun Signal. 2012 Jul 11;10(1):19
pubmed: 22784513
Exp Mol Pathol. 2012 Dec;93(3):294-301
pubmed: 23018130
Oncogene. 2013 Nov 7;32(45):5302-14
pubmed: 23334324
Med Oncol. 2013 Jun;30(2):517
pubmed: 23440723
J Clin Invest. 2013 May;123(5):2064-77
pubmed: 23543058
Eur J Cancer Prev. 2014 May;23(3):173-6
pubmed: 23872954
Toxicol Appl Pharmacol. 2013 Nov 15;273(1):130-9
pubmed: 23993976
Antioxid Redox Signal. 2014 May 10;20(14):2251-73
pubmed: 24206177
Cell Death Differ. 2014 Mar;21(3):427-37
pubmed: 24270408
Biomed Pharmacother. 2014 Feb;68(1):25-30
pubmed: 24332650
J Immunol. 2014 Apr 15;192(8):3686-96
pubmed: 24634491
Int J Oncol. 2014 Dec;45(6):2250-66
pubmed: 25201346
J Steroid Biochem Mol Biol. 2015 Apr;148:275-82
pubmed: 25448738
Basic Clin Pharmacol Toxicol. 2015 Aug;117(2):96-104
pubmed: 25615285
Oncogene. 2016 Jan 14;35(2):206-17
pubmed: 25772234
Cell Rep. 2015 Mar 17;10(10):1722-1734
pubmed: 25772359
PLoS One. 2015 Apr 13;10(4):e0124339
pubmed: 25875760
J Biol Chem. 2015 Jun 12;290(24):14875-83
pubmed: 25922079
Int J Clin Exp Pathol. 2015 Feb 01;8(2):2018-25
pubmed: 25973098
Mol Oncol. 2016 May;10(5):652-62
pubmed: 26733232
Nat Commun. 2016 Mar 18;7:10879
pubmed: 26988444
J Clin Neurosci. 2016 Aug;30:110-114
pubmed: 27050915
J Orthop Res. 2017 Feb;35(2):331-339
pubmed: 27101204
FEBS J. 2016 Jun;283(11):2197-201
pubmed: 27263510
Phytother Res. 2017 Jul;31(7):1072-1077
pubmed: 28504466
Cancer Res. 2017 Sep 1;77(17):4602-4612
pubmed: 28674078
Elife. 2017 Oct 18;6:
pubmed: 29043977
Environ Toxicol. 2018 Mar;33(3):269-279
pubmed: 29165873
Sci Rep. 2018 Feb 14;8(1):2979
pubmed: 29445242
Oncotarget. 2018 Jan 6;9(5):6391-6401
pubmed: 29464080
Nat Commun. 2018 Oct 12;9(1):4231
pubmed: 30315197
J Virol. 2019 Jan 4;93(2):null
pubmed: 30333178
Inflammation. 2019 Feb;42(1):235-245
pubmed: 30411211
Nucleic Acids Res. 2019 Jan 8;47(D1):D100-D105
pubmed: 30445619
Front Neurosci. 2019 Jan 23;13:16
pubmed: 30728764