Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5
Animals
Antimicrobial Cationic Peptides
/ immunology
Bacteria
/ classification
Cell Proliferation
Gastrointestinal Microbiome
Humans
Intestines
/ immunology
Melanoma
/ enzymology
Membrane Proteins
/ deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
Ubiquitin-Protein Ligases
/ deficiency
Unfolded Protein Response
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 04 2019
02 04 2019
Historique:
received:
27
10
2018
accepted:
14
03
2019
entrez:
4
4
2019
pubmed:
4
4
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Accumulating evidence points to an important role for the gut microbiome in anti-tumor immunity. Here, we show that altered intestinal microbiota contributes to anti-tumor immunity, limiting tumor expansion. Mice lacking the ubiquitin ligase RNF5 exhibit attenuated activation of the unfolded protein response (UPR) components, which coincides with increased expression of inflammasome components, recruitment and activation of dendritic cells and reduced expression of antimicrobial peptides in intestinal epithelial cells. Reduced UPR expression is also seen in murine and human melanoma tumor specimens that responded to immune checkpoint therapy. Co-housing of Rnf5
Identifiants
pubmed: 30940817
doi: 10.1038/s41467-019-09525-y
pii: 10.1038/s41467-019-09525-y
pmc: PMC6445090
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Membrane Proteins
0
RNF5 protein, mouse
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1492Subventions
Organisme : NIH HHS
ID : R35CA197465
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106895
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA128814
Pays : United States
Organisme : NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197465
Pays : United States
Organisme : NIH HHS
ID : CA198103
Pays : United States
Organisme : NIH HHS
ID : R01CA216187
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA030199
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103185
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113171
Pays : United States
Organisme : NIH HHS
ID : DK103185
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA216187
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA198103
Pays : United States
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